Existence of activated and memory CD4+ T cells in peripheral blood and their skin infiltration in CD8 deficiency

CD8 deficiency is a rare primary immunodeficiency caused by the defect of a tyrosine kinase, ZAP‐70, which transduces signals from the T cell receptor. We report here a case of CD8 deficiency, having CD4+ T cells with a unique phenotype. The patient's T cells did not respond to anti‐CD3 stimula...

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Bibliographic Details
Published in:Clinical and experimental immunology 1999-01, Vol.115 (1), p.124-130
Main Authors: KATAMURA, K, TAI, G, TACHIBANA, T, YAMABE, H, OHMORI, K, MAYUMI, M, MATSUDA, S, KOYASU, S, FURUSHO, K
Format: Article
Language:English
Subjects:
activated and memory CD4+ T cells
Biological and medical sciences
CD4-Positive T-Lymphocytes - immunology
CD8 Antigens - physiology
CD8 deficiency
Humans
Immune System - immunology
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunologic Deficiency Syndromes - blood
Immunologic Memory
Immunopathology
Infant
Lymphocyte Activation
Male
Medical sciences
Original
Phytohemagglutinins - pharmacology
Protein-Tyrosine Kinases - deficiency
Protein-Tyrosine Kinases - immunology
Receptors, Antigen, T-Cell - deficiency
Skin - immunology
Skin - pathology
skin infiltration
ZAP-70 Protein-Tyrosine Kinase
ZAP‐70
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Summary:CD8 deficiency is a rare primary immunodeficiency caused by the defect of a tyrosine kinase, ZAP‐70, which transduces signals from the T cell receptor. We report here a case of CD8 deficiency, having CD4+ T cells with a unique phenotype. The patient's T cells did not respond to anti‐CD3 stimulation in vitro, suggesting that they were naive. However, many CD4+ T cells with activated and memory phenotypes, which expressed CD45RO+, HLA‐DR+ and CD25+, were present in the peripheral blood, and these cells accumulated in the perivascular area of his infiltrative erythematous skin lesions. The patient's T cells could be activated by a high concentration of phytohaemagglutinin (PHA), indicating the presence of an alternate signalling pathway which bypasses ZAP‐70 and activates CD4+ T cells in vivo. The origin and role of activated CD4+ T cells in the pathogenesis involved in the skin lesions are discussed.
ISSN:0009-9104
1365-2249
DOI:10.1046/j.1365-2249.1999.00759.x