HLA‐DMB expression by thyrocytes: indication of the antigen‐processing and possible presenting capability of thyroid cells

Expression of HLA class II molecules on thyrocytes is a characteristic feature of autoimmune thyroid disease and may lead the thyroid cells to present autoantigens to CD4+ T lymphocytes. Since HLA‐DM is a critical molecule in class II‐restricted antigen processing and presentation, we assessed the e...

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Bibliographic Details
Published in:Clinical and experimental immunology 1999-04, Vol.116 (1), p.62-69
Main Authors: WU, Z., BIRO, P. A., MIRAKIAN, R., HAMMOND, L., CURCIO, F., AMBESI‐IMPIOMBATO, F. S., BOTTAZZO, G. F.
Format: Article
Language:English
Subjects:
Antigen Presentation
Antiporters
Biological and medical sciences
Carrier Proteins - biosynthesis
Chloride-Bicarbonate Antiporters
CIITA
Endocrinopathies
Gene Expression
General aspects
Histocompatibility Antigens Class II
HLA-D Antigens - isolation & purification
HLA‐DMB
Humans
Immunopathology
Medical sciences
Membrane Proteins - biosynthesis
Non tumoral diseases. Target tissue resistance. Benign neoplasms
Nuclear Proteins
Original
Sulfate Transporters
thyrocytes
Thyroid Gland - cytology
Thyroid Gland - immunology
Thyroid. Thyroid axis (diseases)
Trans-Activators - biosynthesis
Up-Regulation
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Summary:Expression of HLA class II molecules on thyrocytes is a characteristic feature of autoimmune thyroid disease and may lead the thyroid cells to present autoantigens to CD4+ T lymphocytes. Since HLA‐DM is a critical molecule in class II‐restricted antigen processing and presentation, we assessed the expression of HLA‐DMB, ‐invariant chain (Ii), class II transactivator (CIITA) and DRA in an untransformed, pure thyrocyte strain HTV‐59A. Here we report that both HLA‐DMB mRNA and the protein are expressed in thyrocytes and that CIITA expression is enhanced by interferon‐gamma (IFN‐γ) treatment and occurs before DMB, Ii and DRA up‐regulation, suggesting CIITA expression is a requirement for antigen processing in thyrocytes. These results indicate that thyrocytes are capable of antigen processing and possibly antigen presentation to T cells.
ISSN:0009-9104
1365-2249
DOI:10.1046/j.1365-2249.1999.00831.x