Humoral immune responses in periodontal disease may have mucosal and systemic immune features

The humoral immune response, especially IgG and IgA, is considered to be protective in the pathogenesis of periodontal disease, but the precise mechanisms are still unknown. Immunoglobulins arriving at the periodontal lesion are from both systemic and local tissue sources. In order to understand bet...

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Bibliographic Details
Published in:Clinical and experimental immunology 1999-03, Vol.115 (3), p.534-541
Main Authors: KINANE, D. F, LAPPIN, D. F, KOULOURI, O, BUCKLEY, A
Format: Article
Language:English
Subjects:
Adult
Aggressive Periodontitis - genetics
Aggressive Periodontitis - immunology
Antibody Formation
Base Sequence
Biological and medical sciences
Facial bones, jaws, teeth, parodontium: diseases, semeiology
Humans
IgA subclass
IgG subclass
Immunity, Mucosal
Immunoglobulin A - biosynthesis
Immunoglobulin A - classification
Immunoglobulin A - genetics
Immunoglobulin E - biosynthesis
Immunoglobulin E - genetics
Immunoglobulin G - biosynthesis
Immunoglobulin G - classification
Immunoglobulin G - genetics
Immunoglobulin J-Chains - genetics
Immunoglobulin M - biosynthesis
Immunoglobulin M - genetics
Immunohistochemistry
In Situ Hybridization
Medical sciences
Middle Aged
Non tumoral diseases
Oligonucleotide Probes - genetics
Original
Otorhinolaryngology. Stomatology
periodontitis
Periodontitis - genetics
Periodontitis - immunology
RNA, Messenger - genetics
RNA, Messenger - metabolism
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Summary:The humoral immune response, especially IgG and IgA, is considered to be protective in the pathogenesis of periodontal disease, but the precise mechanisms are still unknown. Immunoglobulins arriving at the periodontal lesion are from both systemic and local tissue sources. In order to understand better the local immunoglobulin production, we examined biopsy tissue from periodontitis lesions for the expression of IgM, IgG, IgA, IgE and in addition the IgG and IgA subclasses and J‐chain by in situ hybridization. Tissues examined were superficial inflamed gingiva and the deeper granulation tissue from periodontal sites. These data confirm that IgM, and IgG and IgA subclass proteins and J‐chain can be locally produced in the periodontitis tissues. IgG1 mRNA‐expressing cells were predominant in the granulation tissues and in the gingiva, constituting approx. 65% of the total IgG‐expressing plasma cells. There was a significantly increased proportion of IgA‐expressing plasma cells in the gingiva compared with the granulation tissue (P 
ISSN:0009-9104
1365-2249
DOI:10.1046/j.1365-2249.1999.00819.x