HLA‐DRB1 leprogenic motifs in Nigerian population groups

Amino acid residues involved in the peptide binding groove of HLA‐DRB1 alleles were examined in three Nigerian ethnic groups with leprosy (n = 287) and 170 controls to determine the role of DRB1 alleles in disease outcome with Mycobacterium leprae. Nine positively charged motifs and two others with...

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Bibliographic Details
Published in:Clinical and experimental immunology 1999-10, Vol.118 (1), p.56-62
Main Authors: UKO, G. P, LU, L.-Y, FRASER, P. A, ASUQUO, M. A, FICI, D, MAHAN, S, AWDEH, Z, UDIM, E. R, DING, W, UMANA, U, ADEWOLE, T
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Alleles
Amino Acid Motifs - immunology
Bacterial diseases
Binding Sites - immunology
Biological and medical sciences
Epitopes - immunology
Female
Gene Frequency - immunology
histocompatibility locus HLA
Histocompatibility Testing
HLA-DR Antigens - genetics
HLA-DRB1 Chains
HLA‐DRB1
Human bacterial diseases
Humans
Infectious diseases
leprogenic motif
Leprosy
Leprosy - genetics
Leprosy - immunology
Male
Medical sciences
Middle Aged
Mycobacterium leprae
net charge
Nigeria
Nigeria - ethnology
Original
shared epitope
Tropical bacterial diseases
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Summary:Amino acid residues involved in the peptide binding groove of HLA‐DRB1 alleles were examined in three Nigerian ethnic groups with leprosy (n = 287) and 170 controls to determine the role of DRB1 alleles in disease outcome with Mycobacterium leprae. Nine positively charged motifs and two others with neutral charge to the binding groove were detected. These motifs occurred more frequently in leprosy (leprogenic) than was expected by chance (P 
ISSN:0009-9104
1365-2249
DOI:10.1046/j.1365-2249.1999.01034.x