Anti‐MHC autoimmunity in Behçet’s disease: T cell responses to an HLA‐B‐derived peptide cross‐reactive with retinal‐S antigen in patients with uveitis

Immune response to retinal autoantigens plays a central role in the pathogenesis of uveitis. A synthetic peptide (B27PD) from a common sequence of various HLA‐B molecules associated with uveitis, such as HLA‐B27 and 51, which shares amino acid homologies with a retinal‐S antigen (S‐Ag)‐derived pepti...

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Bibliographic Details
Published in:Clinical and experimental immunology 2000-04, Vol.120 (1), p.162-166
Main Authors: Kurhan‐Yavuz, S., Direskeneli, H., Bozkurt, N., Özyazgan, Y., Bavbek, T., Kazokoglu, H., Eksioglu‐Demiralp, E., Wildner, G., Diedrichs‐Möhring, M., Akoglu, T.
Format: Article
Language:English
Subjects:
Adult
Arrestin - chemistry
Arrestin - immunology
Autoimmune Diseases - immunology
B51
Behcet Syndrome - immunology
Behçet’s disease
Cell Division - immunology
Cells, Cultured
Culture Media, Conditioned - chemistry
Female
histocompatibility antigen HLA
HLA-B Antigens - chemistry
HLA-B Antigens - immunology
HLA-B27 Antigen - chemistry
HLA-B27 Antigen - immunology
HLA-B51 Antigen
HLA‐B27
Humans
Interleukin-2 - metabolism
Lymphocyte Activation - immunology
Major Histocompatibility Complex - immunology
Male
Retina - immunology
retinal autoimmunity
retinal-S antigen
Rheumatic Disease
Tumor Necrosis Factor-alpha - metabolism
uveitis
Uveitis, Anterior - immunology
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Summary:Immune response to retinal autoantigens plays a central role in the pathogenesis of uveitis. A synthetic peptide (B27PD) from a common sequence of various HLA‐B molecules associated with uveitis, such as HLA‐B27 and 51, which shares amino acid homologies with a retinal‐S antigen (S‐Ag)‐derived peptide (PDSAg), was shown to be immunogenic in human and experimental uveitis in the rat. In this study we investigated T cell responses to B27PD and PDSAg in patients with Behçet’s disease and posterior uveitis (BD‐posterior uveitis; n = 33) in comparison with non‐Behçet anterior uveitis (AU, n = 14), Behçet’s patients without uveitis (BD, n = 15) and healthy controls (HC, n = 32) in a 6‐day proliferation assay. Patients with BD and posterior uveitis had significantly higher responses (stimulation index (SI) 2·8 ± 1·3) than those with AU (SI 1·5 ± 0·4), BD without uveitis (SI 1·1 ± 0·4) and HC (SI 1·1 ± 0·6) for B27PD (P 
ISSN:0009-9104
1365-2249
DOI:10.1046/j.1365-2249.2000.01176.x