Deficiency in circulating natural killer (NK) cell subsets in common variable immunodeficiency and X‐linked agammaglobulinaemia

Absolute and relative NK cell numbers were determined in peripheral whole blood by flow cytometry in patients with common variable immunodeficiency (CVID) (n = 55) and X‐linked agammaglobulinaemia (XLA) (n = 19) on regular immunoglobulin (IVIG) therapy. Absolute CD3−CD16+ NK cell numbers were signif...

Full description

Saved in:
Bibliographic Details
Published in:Clinical and experimental immunology 2000-09, Vol.121 (3), p.506-514
Main Authors: Aspalter, R. M., Sewell, W. A. C., Dolman, K., Farrant, J., Webster, A. D. B.
Format: Article
Language:English
Subjects:
Adult
Agammaglobulinemia - genetics
Agammaglobulinemia - immunology
Agammaglobulinemia - therapy
Antibodies, Monoclonal - metabolism
Binding, Competitive
Biological and medical sciences
Case-Control Studies
CD16
common variable immunodeficiency
Common Variable Immunodeficiency - immunology
Common Variable Immunodeficiency - therapy
Female
Genetic Linkage
Humans
Immunodeficiencies. Immunoglobulinopathies
Immunodeficiency
Immunoglobulin G - metabolism
Immunoglobulinopathies
Immunoglobulins, Intravenous - therapeutic use
Immunopathology
In Vitro Techniques
interferon‐gamma
intravenous immunoglobulin therapy
Killer Cells, Natural - classification
Killer Cells, Natural - immunology
Male
Medical sciences
natural killer cells
Receptors, IgG - immunology
X Chromosome - genetics
X-linked agammaglobulinemia
X‐linked agammaglobulinaemia
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Absolute and relative NK cell numbers were determined in peripheral whole blood by flow cytometry in patients with common variable immunodeficiency (CVID) (n = 55) and X‐linked agammaglobulinaemia (XLA) (n = 19) on regular immunoglobulin (IVIG) therapy. Absolute CD3−CD16+ NK cell numbers were significantly reduced in CVID patients (median 108/μl, range 23–815), compared with normal subjects (n = 60) (289/μl, range 56–640, P 
ISSN:0009-9104
1365-2249
DOI:10.1046/j.1365-2249.2000.01317.x