Age‐related differences in cell‐specific cytokine production by acutely ill Malawian patients

SUMMARY Age‐related changes in human cell‐specific cytokine responses to acute illness have not been well examined. We therefore evaluated age‐related differences in T, B and natural killer (NK) peripheral blood lymphocyte cytokine responses of 309 acutely ill hospitalized people in Malawi, Africa,...

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Bibliographic Details
Published in:Clinical and experimental immunology 2002-04, Vol.128 (1), p.110-117
Main Authors: PETTIFORD, J. N., JASON, J., NWANYANWU, O. C., ARCHIBALD, L. K., KAZEMBE, P. N., DOBBIE, H., JARVIS, W. R.
Format: Article
Language:English
Subjects:
Acute Disease
Adolescent
Adult
age
Aging - immunology
B-Lymphocytes - immunology
Biological and medical sciences
CD3 Complex - analysis
CD8-Positive T-Lymphocytes - immunology
Child
Child, Preschool
cytokine balance
Cytokines - biosynthesis
Female
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Humans
IFN‐γ IL‐8 immunosenescence T lymphocytes
Immunobiology
Infant
Infant, Newborn
Interferon-gamma - biosynthesis
Interleukin-2 - biosynthesis
Interleukin-8 - biosynthesis
Killer Cells, Natural - immunology
Lymphocytes - immunology
Malawi
Male
Middle Aged
Modulation of the immune response (stimulation, suppression)
Original
T-Lymphocytes, Helper-Inducer - immunology
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Summary:SUMMARY Age‐related changes in human cell‐specific cytokine responses to acute illness have not been well examined. We therefore evaluated age‐related differences in T, B and natural killer (NK) peripheral blood lymphocyte cytokine responses of 309 acutely ill hospitalized people in Malawi, Africa,
ISSN:0009-9104
1365-2249
DOI:10.1046/j.1365-2249.2002.01813.x