Synthesis and anticonvulsant activity of some potent 5,6-bis aryl 1,2,4-triazines

In the present research, a series of 5,6-bis aryl 1,2,4-triazines 5a~5f were synthesized by condensation of various benzils 4a~4f with aminoguanidine bicarbonate and were screened in vivo, for their anticonvulsant and neurotoxicity studies. Compounds 5a, 5b and 5d were found to be potent molecules o...

Full description

Saved in:
Bibliographic Details
Published in:Journal of Zhejiang University. B. Science 2007-07, Vol.8 (7), p.526-532
Main Authors: Mallikarjuna, B P, Suresh Kumar, G V, Sastry, B S, Nagaraj, Manohara, K P
Format: Article
Language:English
Subjects:
Animals
Anticonvulsants - chemical synthesis
Anticonvulsants - chemistry
Anticonvulsants - pharmacology
Anticonvulsants - toxicity
Behavior, Animal - drug effects
Drug Evaluation, Preclinical
Magnetic Resonance Spectroscopy
Mice
Molecular Structure
Motor Activity - drug effects
Pharmaceutical Sciences
Rats
Seizures - prevention & control
Spectrometry, Mass, Electrospray Ionization
Triazines - chemical synthesis
Triazines - chemistry
Triazines - pharmacology
Triazines - toxicity
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In the present research, a series of 5,6-bis aryl 1,2,4-triazines 5a~5f were synthesized by condensation of various benzils 4a~4f with aminoguanidine bicarbonate and were screened in vivo, for their anticonvulsant and neurotoxicity studies. Compounds 5a, 5b and 5d were found to be potent molecules of this series, when compared with the reference drugs phenytoin sodium, diazepam and lamotrigine. The structures of these compounds were established by IR, (1)H NMR, (13)C NMR and mass spectroscopic data.
ISSN:1673-1581
1862-1783
DOI:10.1631/jzus.2007.B0526