Anti-vpr activities of heat shock protein 27

HIV-1 Vpr plays a pivotal role in viral pathogenesis and is preferentially targeted by the host immune system. In this report, we demonstrate that a small heat shock protein, HSP27, exhibits Vpr-specific antiviral activity, as its expression is specifically responsive to vpr gene expression and incr...

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Bibliographic Details
Published in:Molecular medicine (Cambridge, Mass.) Mass.), 2007-05, Vol.13 (5-6), p.229-239
Main Authors: Liang, Dong, Benko, Zsigmond, Agbottah, Emmanuel, Bukrinsky, Michael, Zhao, Richard Y
Format: Article
Language:English
Subjects:
Apoptosis
Cell Line
DNA-Binding Proteins - metabolism
G2 Phase
Gene Expression
Gene Products, vpr - antagonists & inhibitors
Heat Shock Transcription Factors
Heat-Shock Proteins - metabolism
Heat-Shock Response
HIV Infections
HIV-1 - physiology
Humans
T-Lymphocytes - virology
Transcription Factors - metabolism
Virus Replication
vpr Gene Products, Human Immunodeficiency Virus
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Summary:HIV-1 Vpr plays a pivotal role in viral pathogenesis and is preferentially targeted by the host immune system. In this report, we demonstrate that a small heat shock protein, HSP27, exhibits Vpr-specific antiviral activity, as its expression is specifically responsive to vpr gene expression and increased levels of HSP27 inhibit Vpr-induced cell cycle G2 arrest and cell killing. We further show that overexpression of HSP27 reduces viral replication in T-lymphocytes in a Vpr-dependent manner. Mechanistically, Vpr triggers HSP27 expression through heat shock factor (HSF) 1, but inhibits prolonged expression of HSP27 under heat-shock conditions. Together, these data suggest a potential dynamic and antagonistic interaction between HIV-1 Vpr and a host cell HSP27, suggesting that HSP27 may contribute to cellular intrinsic immunity against HIV infection.
ISSN:1076-1551
1528-3658
DOI:10.2119/2007-00004.Liang