Changes in plasma catecholamine and neuropeptide Y levels after sympathetic activation in dogs

• Published in: British journal of pharmacology 1992-01, Vol.105 (1), p.181-183
• Main Authors: Poncet, Marie‐France, Damase‐Michel, Christine, Tavernier, Genevieve, Tran, Marie‐Antoinette, Berlan, Michel, Montastruc, Jean‐Louis, Montastruc, Paul
• Format: Article
• Language: English
• Subjects: Animals; Aorta - innervation; Biological and medical sciences; Blood Pressure - drug effects; Blood Pressure - physiology; Carotid Sinus - innervation; Catecholamines; Catecholamines - blood; Dogs; Female; Fundamental and applied biological sciences. Psychology; Heart Rate - drug effects; Heart Rate - physiology; Male; Muscle Denervation; neuropeptide Y; Neuropeptide Y - blood; noradrenaline; Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ; Radioimmunoassay; sinoaortic denervation; sympathetic nervous system; Sympathetic Nervous System - physiology; Vertebrates: nervous system and sense organs; yohimbine; Yohimbine - pharmacology
• ISSN: 0007-1188; 1476-5381
• DOI: 10.1111/j.1476-5381.1992.tb14232.x

1 Plasma levels of noradrenaline (NA) and neuropeptide Y (NPY) were evaluated in two experimental models associated with an increase in sympathetic tone: conscious dogs which were subject to either sinoaortic denervation or acute administration of the α2‐adrenoceptor antagonist yohimbine. 2 Dogs that had undergone sinoaortic denervation exhibited a two fold increase in plasma NA without any change in NPY levels. 3 Yohimbine (0.05 mg kg−1 i.v. as a bolus) produced similar effects. A higher dose of yohimbine (0.5 mg kg−1 i.v.) increased both plasma NA (7 fold) and NPY (6.5 fold) levels. 4 The present results indicate that changes in plasma catecholamines and NPY are not always concomitant. They suggest that the simultaneous release of NA and NPY is only observed under in vivo conditions for a marked increase in sympathetic tone.