Influence of pertussis toxin on the calcitonin‐opioid interaction in isolated tissues

1 In order to clarify one of the mechanisms involved in the analgesic effect of calcitonin, we have tested the in vitro modifications induced by calcitonin on the effect of opioids. 2 The inhibition of the contractions induced by opioids or clonidine, in guinea‐pig ileum or in mouse vas deferens, we...

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Bibliographic Details
Published in:British journal of pharmacology 1996-11, Vol.119 (5), p.804-806
Main Authors: Martín, M.I., Goicoechea, C., Ormazábal, M.J., Alfaro, M.J.
Format: Article
Language:English
Subjects:
Adrenergic alpha-2 Receptor Agonists
Adrenergic alpha-Agonists - metabolism
Adrenergic alpha-Agonists - pharmacology
Analgesics
Animals
Biological and medical sciences
Bordetella pertussis
Calcitonin - metabolism
calcitonin analgesia
clonidine
Clonidine - metabolism
Clonidine - pharmacology
Guinea Pigs
G‐proteins
In Vitro Techniques
Male
Medical sciences
Mice
Neuropharmacology
opioid
Pertussis Toxin
Pharmacology. Drug treatments
Receptors, Opioid - metabolism
Virulence Factors, Bordetella - pharmacology
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Summary:1 In order to clarify one of the mechanisms involved in the analgesic effect of calcitonin, we have tested the in vitro modifications induced by calcitonin on the effect of opioids. 2 The inhibition of the contractions induced by opioids or clonidine, in guinea‐pig ileum or in mouse vas deferens, were significantly reduced in tissues incubated with pertussis toxin (PTX). When tissues were incubated with PTX and calcitonin, the inhibitory effect was restored. 3 These results suggest that calcitonin is able to potentiate a non‐PTX‐sensitive mechanism of transduction and support the possibility of involvement of similar G‐proteins in the effects of opioid and α2‐adrenoceptor agonists.
ISSN:0007-1188
1476-5381
DOI:10.1111/j.1476-5381.1996.tb15743.x