Carbenoxolone and deglycyrrhized liquorice have little or no effect on prostanoid synthesis by rat gastric mucosa ex vivo

1 Rats were given either carbenoxolone 50 mg kg−1, deglycyrrhized liquorice 1 g kg−1 or vehicle by gastric tube. The doses were repeated 16 h later, and the stomachs removed after another 2 h. 2 The amounts of prostaglandin E (PGE), 6‐keto‐PGF1α and thromboxane B2, measured by radioimmunoassay in ex...

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Bibliographic Details
Published in:British journal of pharmacology 1985-11, Vol.86 (3), p.693-695
Main Authors: Bennett, Alan, Melhuish, Pauline B., Stamford, Ian F.
Format: Article
Language:English
Subjects:
6-Ketoprostaglandin F1 alpha - biosynthesis
Animals
Anti-Ulcer Agents - pharmacology
Biological and medical sciences
Carbenoxolone - pharmacology
Digestive system
Gastric Mucosa - drug effects
Gastric Mucosa - metabolism
Glycyrrhetinic Acid - analogs & derivatives
Glycyrrhiza
Male
Medical sciences
Pharmacology. Drug treatments
Plant Extracts - pharmacology
Plants, Medicinal
Prostaglandins - biosynthesis
Prostaglandins E - biosynthesis
Rats
Rats, Inbred Strains
Thromboxane B2 - biosynthesis
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Summary:1 Rats were given either carbenoxolone 50 mg kg−1, deglycyrrhized liquorice 1 g kg−1 or vehicle by gastric tube. The doses were repeated 16 h later, and the stomachs removed after another 2 h. 2 The amounts of prostaglandin E (PGE), 6‐keto‐PGF1α and thromboxane B2, measured by radioimmunoassay in extracts of the gastric corpus and antrum mucosa, were similar in the treated animals and the controls. 3 We conclude that in rats, carbenoxolone and deglycyrrhized liquorice may exert their anti‐ulcer effect by a non‐prostaglandin mechanism. This contrasts with the mechanism thought to occur in man with carbenoxolone.
ISSN:0007-1188
1476-5381
DOI:10.1111/j.1476-5381.1985.tb08947.x