The effect of α,β‐methylene ATP on the depolarization evoked by noradrenaline (γ‐adrenoceptor response) and ATP in the immature rat basilar artery

Depolarizations evoked by noradrenaline that were resistant to α‐ and β‐adrenoceptor antagonists were recorded in the rat basilar artery. These γ‐adrenoceptor‐mediated responses and the depolarizations to adenosine triphosphate (ATP) were blocked by pretreatment of the tissue with α,β‐methylene ATP....

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Bibliographic Details
Published in:British journal of pharmacology 1986-05, Vol.88 (1), p.6-8
Main Authors: Byrne, N.G., Large, W.A.
Format: Article
Language:English
Subjects:
Adenosine Triphosphate - analogs & derivatives
Adenosine Triphosphate - pharmacology
Animals
Applied sciences
Ascorbic Acid - pharmacology
Basilar Artery - drug effects
Biological and medical sciences
Catecholaminergic system
Edetic Acid - pharmacology
Exact sciences and technology
In Vitro Techniques
Male
Medical sciences
Membrane Potentials - drug effects
Muscle, Smooth, Vascular - drug effects
Neuromuscular Depolarizing Agents
Neuropharmacology
Neurotransmitters. Neurotransmission. Receptors
Norepinephrine - pharmacology
Other techniques and industries
Pharmacology. Drug treatments
Phentolamine - pharmacology
Propranolol - pharmacology
Rats
Receptors, Cell Surface - metabolism
Receptors, Purinergic
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Summary:Depolarizations evoked by noradrenaline that were resistant to α‐ and β‐adrenoceptor antagonists were recorded in the rat basilar artery. These γ‐adrenoceptor‐mediated responses and the depolarizations to adenosine triphosphate (ATP) were blocked by pretreatment of the tissue with α,β‐methylene ATP. These data are discussed with respect to the selectivity of α,β‐methylene ATP.
ISSN:0007-1188
1476-5381
DOI:10.1111/j.1476-5381.1986.tb09464.x