The power of interval mapping of quantitative trait loci, using selected sib pairs

The interval-mapping procedure of Fulker and Cardon for analysis of a quantitative-trait loci (QTL) is extended for application to selected samples of sib pairs. Phenotypic selection of sib pairs, which is known to yield striking increases in power when a single marker is used, provides further incr...

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Bibliographic Details
Published in:American journal of human genetics 1994-10, Vol.55 (4), p.825-833
Main Authors: CARDON, L. R, FULKER, D. W
Format: Article
Language:English
Subjects:
Algorithms
Alleles
Biological and medical sciences
Classical genetics, quantitative genetics, hybrids
Fundamental and applied biological sciences. Psychology
Gene Frequency
Genes, Recessive
Genetic Carrier Screening
Genetics of eukaryotes. Biological and molecular evolution
Genetics, Medical - methods
Genotype
Human
Humans
Mathematics
Models, Genetic
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Summary:The interval-mapping procedure of Fulker and Cardon for analysis of a quantitative-trait loci (QTL) is extended for application to selected samples of sib pairs. Phenotypic selection of sib pairs, which is known to yield striking increases in power when a single marker is used, provides further increases in power when the interval-mapping approach is used. The greatest benefits of the combined approach are apparent with coarse maps, where QTLs of relatively modest (15%-20%) heritability can be detected with widely spaced markers (40-60 cM apart) in reasonably sized sibling samples. Useful information concerning QTL location is afforded by interval mapping in both selected and unselected samples.
ISSN:0002-9297
1537-6605