CURRENT STATUS OF MEASLES AND ORAL POLIOVIRUS VACCINES

Live attenuated measles vaccine, accompanied by a dose of gamma globulin to reduce systemic reactions, has given a high degree of protection, probably long lasting. Further attenuated vaccine gives promise of achieving the same result without the use of gamma globulin. Inactivated vaccine has not be...

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Bibliographic Details
Published in:Canadian Medical Association journal 1964-11, Vol.91 (21), p.1118-1122
Main Author: MACLEOD, D R
Format: Article
Language:English
Subjects:
Adult
Canada
Child
gamma-Globulins
Humans
Immunization
Infant
Measles
Measles Vaccine
Old Medline
Poliovirus
Poliovirus Vaccine, Inactivated
Poliovirus Vaccine, Oral
Review
Vaccination
Vaccines
Vaccines, Attenuated
Vaccines, Inactivated
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Summary:Live attenuated measles vaccine, accompanied by a dose of gamma globulin to reduce systemic reactions, has given a high degree of protection, probably long lasting. Further attenuated vaccine gives promise of achieving the same result without the use of gamma globulin. Inactivated vaccine has not been shown to give durable immunity, but a schedule of killed vaccine followed by live vaccine has provided protection with minimal reactions. Inactivated vaccine can probably be combined with other antigens.Sabin oral poliovirus vaccines of all three types have been highly effective in preventing paralytic illness and reducing the spread of virulent strains. Because of the rare occurrence, chiefly in adults, of paralytic cases considered to be probably vaccine-associated, though no proof was possible, it has been recommended in Canada that initial immunization with Salk vaccine be continued and that all infants and children should subsequently receive trivalent Sabin vaccine.
ISSN:0008-4409