Inflammation, demyelination, neurodegeneration and neuroprotection in the pathogenesis of multiple sclerosis

Abstract Although axonal loss has been observed in demyelinated multiple sclerosis (MS) lesions, there has been a major focus on understanding mechanisms of demyelination. However, identification of markers for axonal damage and development of new imaging techniques has enabled detection of subtle c...

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Bibliographic Details
Published in:Journal of neuroimmunology 2007-03, Vol.184 (1), p.37-44
Main Authors: Peterson, Lisa K, Fujinami, Robert S
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
CNS demyelinating autoimmune disease
Demyelinating Diseases
Disease Models, Animal
Experimental autoimmune encephalomyelitis
Humans
Inflammation
Multiple sclerosis
Multiple Sclerosis - etiology
Multiple Sclerosis - microbiology
Multiple Sclerosis - pathology
Multiple Sclerosis - prevention & control
Nerve Degeneration
Neurology
Neuron degeneration
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Summary:Abstract Although axonal loss has been observed in demyelinated multiple sclerosis (MS) lesions, there has been a major focus on understanding mechanisms of demyelination. However, identification of markers for axonal damage and development of new imaging techniques has enabled detection of subtle changes in axonal pathology and revived interest in the neurodegenerative component of MS. Axonal loss is generally accepted as the main determinant of permanent clinical disability. However, the role of axonal loss early in disease or during relapsing–remitting disease is still under investigation, as are the interactions and interdependency between inflammation, demyelination, neurodegeneration and neuroprotection in the pathogenesis of MS.
ISSN:0165-5728
1872-8421
DOI:10.1016/j.jneuroim.2006.11.015