Autonomic nervous system and secretion across the intestinal mucosal surface

Abstract Chloride secretion is important because it is the driving force for fluid movement into the intestinal lumen. The flow of accumulated fluid flushes out invading micro-organisms in defense of the host. Chloride secretion is regulated by neurons in the submucosal plexus of the enteric nervous...

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Bibliographic Details
Published in:Autonomic neuroscience 2007-04, Vol.133 (1), p.55-63
Main Authors: Xue, Jianjing, Askwith, Candice, Javed, Najma H, Cooke, Helen J
Format: Article
Language:English
Subjects:
5-Hydroxytryptamine
Advanced Basic Science
Animals
Autonomic Nervous System - cytology
Autonomic Nervous System - physiology
Chloride
Chlorides - metabolism
Enteric nerves
Humans
Intestinal Mucosa - physiology
Intestinal secretion
Medical Education
Neurons - physiology
Serotonin - metabolism
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Summary:Abstract Chloride secretion is important because it is the driving force for fluid movement into the intestinal lumen. The flow of accumulated fluid flushes out invading micro-organisms in defense of the host. Chloride secretion is regulated by neurons in the submucosal plexus of the enteric nervous system. Mechanosensitive enterochromaffin cells that release 5-hydroxytryptamine (5-HT) and activate intrinsic afferent neurons in the submucosal plexus and initiate chloride secretion. Mechanical stimulation by distention may also trigger reflexes by a direct action on intrinsic afferent neurons. Dysregulation of 5-HT release or altered activity of intrinsic afferents is likely to occur in states of inflammation and other disorders.
ISSN:1566-0702
1872-7484
DOI:10.1016/j.autneu.2007.02.001