Repeated social defeat causes increased anxiety-like behavior and alters splenocyte function in C57BL/6 and CD-1 mice

Abstract The experimental model, social disruption (SDR), is a model of social stress in which mice are repeatedly attacked and defeated in their home cage by an aggressive conspecific. In terms of the impact of this stressor on the immune response, SDR has been reported to cause hyperinflammation a...

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Bibliographic Details
Published in:Brain, behavior, and immunity behavior, and immunity, 2007-05, Vol.21 (4), p.458-466
Main Authors: Kinsey, Steven G, Bailey, Michael T, Sheridan, John F, Padgett, David A, Avitsur, Ronit
Format: Article
Language:English
Subjects:
Aggression
Allergy and Immunology
Analysis of Variance
Animals
Anxiety
Anxiety - etiology
Anxiety - immunology
Anxiety - physiopathology
Bullying
Depression
Depression - etiology
Depression - immunology
Depression - physiopathology
Dominance-Subordination
Male
Mice
Mice, Inbred C57BL
Psychiatry
Social Behavior
Social defeat
Social disruption
Social stress
Species Specificity
Spleen - cytology
Spleen - physiopathology
Strain differences
Stress, Psychological - complications
Stress, Psychological - immunology
Stress, Psychological - physiopathology
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Summary:Abstract The experimental model, social disruption (SDR), is a model of social stress in which mice are repeatedly attacked and defeated in their home cage by an aggressive conspecific. In terms of the impact of this stressor on the immune response, SDR has been reported to cause hyperinflammation and glucocorticoid insensitivity. To this point however, the behavioral consequences of SDR have not been thoroughly characterized. Because social defeat has been reported to cause anxiety- and depressive-like behaviors, the current study was designed to assess whether SDR also causes anxiety- and depressive-like behaviors. Using the light/dark preference test and the open field test as tools to measure behaviors characteristic of anxiety, the data showed that C57BL/6 and CD-1 male mice subjected to SDR displayed increased anxiety-like behavior. The increase in anxiety-like behaviors persisted for at least 1 week after the cessation of the stressor. In contrast, depressive-like behaviors were not elicited by SDR as assessed by the forced swim test or the tail suspension test. These data indicate that social disruption stress causes an increase in anxiety-like behaviors, but not depressive-like behaviors.
ISSN:0889-1591
1090-2139
DOI:10.1016/j.bbi.2006.11.001