Mucosal lymphocyte subsets and HLA‐DR antigen expression in paediatric Helicobacter pylori‐associated gastritis

Summary Paediatric studies may provide important insights into the immunopathology of Helicobacter pylori‐associated gastritis, as mucosal changes reflect different stages of the immunoinflammatory response. We characterized, by quantitative immunohistochemistry, gastric mucosal lymphocyte phenotype...

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Bibliographic Details
Published in:Clinical and experimental immunology 2006-07, Vol.145 (1), p.13-20
Main Authors: Lopes, A. I., Victorino, R. M. M., Palha, A. M., Ruivo, J., Fernandes, A.
Format: Article
Language:English
Subjects:
Adolescent
Antibodies, Bacterial - blood
Biological and medical sciences
Case-Control Studies
Child
Child, Preschool
Clinical Studies
Female
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Gastric Mucosa - immunology
Gastric Mucosa - pathology
gastritis
Gastritis - immunology
Gastritis - pathology
Helicobacter Infections - immunology
Helicobacter Infections - pathology
Helicobacter pylori
Helicobacter pylori - immunology
HLA-DR Antigens - analysis
HLA‐DR antigen expression
Humans
Immunoglobulin G - blood
Immunohistochemistry - methods
Immunopathology
Immunophenotyping
Infant
Lymphocyte Count
lymphocyte subsets
Male
Medical sciences
paediatric
Pyloric Antrum - immunology
Pyloric Antrum - pathology
Statistics, Nonparametric
T-Lymphocyte Subsets - immunology
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Summary:Summary Paediatric studies may provide important insights into the immunopathology of Helicobacter pylori‐associated gastritis, as mucosal changes reflect different stages of the immunoinflammatory response. We characterized, by quantitative immunohistochemistry, gastric mucosal lymphocyte phenotype and HLA‐DR antigen expression and evaluated correlation with histopathology, in H. pylori‐infected (Hp+ve) and uninfected children (Hp–ve). In the infected group, lamina propria CD3+ and IgA plasmocyte cell numbers were significantly higher and a trend for predominance of CD8+ over CD4+ was observed both in epithelium and lamina propria. A correlation of inflammation score with lamina propria CD3+ and CD4+ cell numbers and of CD45RO+ T lymphocytes with density of colonization was observed. The proportion of epithelial cells expressing HLA‐DR antigen was significantly higher in the Hp+ve group and furthermore, glandular HLA‐DR expression correlated with lamina propria CD3+ cell numbers, emphasizing the potential role of epithelial cells as antigen‐presenting cells at this stage of infection.
ISSN:0009-9104
1365-2249
DOI:10.1111/j.1365-2249.2006.03100.x