Impact of chronic nicotine on sciatic nerve injury in the rat

Abstract Chronic nicotine exposure and the immune response to peripheral nerve injury has not been investigated thoroughly. Rats were exposed to chronic nicotine or saline followed by chronic constriction injury (CCI) of the sciatic nerve. Mechanical sensitivity was measured at various time points a...

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Bibliographic Details
Published in:Journal of neuroimmunology 2007-05, Vol.186 (1), p.37-44
Main Authors: Brett, Kyle, Parker, Renée, Wittenauer, Shannon, Hayashida, Ken-ichiro, Young, Tracey, Vincler, Michelle
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Behavior, Animal
Constriction
Cytokines - metabolism
Functional Laterality
Hyperalgesia - etiology
Macrophages
Male
Microglia
Microglia - drug effects
Neurology
Neuropathic pain
Nicotine - administration & dosage
Nicotinic Agonists - administration & dosage
Pain Threshold - drug effects
Rats
Rats, Sprague-Dawley
Rodent
Sciatic Neuropathy - complications
Sciatic Neuropathy - immunology
Sciatic Neuropathy - metabolism
Smoking
T cells
Time Factors
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Summary:Abstract Chronic nicotine exposure and the immune response to peripheral nerve injury has not been investigated thoroughly. Rats were exposed to chronic nicotine or saline followed by chronic constriction injury (CCI) of the sciatic nerve. Mechanical sensitivity was measured at various time points and the immune response was investigated at 21 days post-CCI. Chronic nicotine increased mechanical hypersensitivity, microglia activation, and the production of IL-1β, but not the number of immune cells at the site of injury. These results suggest that chronic nicotine increases mechanical hypersensitivity following peripheral nerve injury through a mechanism that may involve an increased production and release of central and peripheral cytokines.
ISSN:0165-5728
1872-8421
DOI:10.1016/j.jneuroim.2007.02.005