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Heterogeneity of a Campylobacter jejuni Protein That Is Secreted through the Flagellar Filament
Cj0859c, or FspA, is a small, acidic protein of Campylobacter jejuni that is expressed by a σ²⁸ promoter. Analysis of the fspA gene in 41 isolates of C. jejuni revealed two overall variants of the predicted protein, FspA1 and FspA2. Secretion of FspA occurs in broth-grown bacteria and requires a min...
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Published in: | Infection and Immunity 2007-08, Vol.75 (8), p.3859-3867 |
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Main Authors: | , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Cj0859c, or FspA, is a small, acidic protein of Campylobacter jejuni that is expressed by a σ²⁸ promoter. Analysis of the fspA gene in 41 isolates of C. jejuni revealed two overall variants of the predicted protein, FspA1 and FspA2. Secretion of FspA occurs in broth-grown bacteria and requires a minimum flagellar structure. The addition of recombinant FspA2, but not FspA1, to INT407 cells in vitro resulted in a rapid induction of apoptosis. These data define a novel C. jejuni virulence factor, and the observed heterogeneity among fspA alleles suggests alternate virulence potential among different strains. |
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ISSN: | 0019-9567 1098-5522 |
DOI: | 10.1128/IAI.00159-07 |