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Heterogeneity of a Campylobacter jejuni Protein That Is Secreted through the Flagellar Filament

Cj0859c, or FspA, is a small, acidic protein of Campylobacter jejuni that is expressed by a σ²⁸ promoter. Analysis of the fspA gene in 41 isolates of C. jejuni revealed two overall variants of the predicted protein, FspA1 and FspA2. Secretion of FspA occurs in broth-grown bacteria and requires a min...

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Bibliographic Details
Published in:Infection and Immunity 2007-08, Vol.75 (8), p.3859-3867
Main Authors: Poly, Frédéric, Ewing, Cheryl, Goon, Scarlett, Hickey, Thomas E, Rockabrand, David, Majam, Gary, Lee, Lanfong, Phan, Julie, Savarino, Nicholas J, Guerry, Patricia
Format: Article
Language:English
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Summary:Cj0859c, or FspA, is a small, acidic protein of Campylobacter jejuni that is expressed by a σ²⁸ promoter. Analysis of the fspA gene in 41 isolates of C. jejuni revealed two overall variants of the predicted protein, FspA1 and FspA2. Secretion of FspA occurs in broth-grown bacteria and requires a minimum flagellar structure. The addition of recombinant FspA2, but not FspA1, to INT407 cells in vitro resulted in a rapid induction of apoptosis. These data define a novel C. jejuni virulence factor, and the observed heterogeneity among fspA alleles suggests alternate virulence potential among different strains.
ISSN:0019-9567
1098-5522
DOI:10.1128/IAI.00159-07