The relationship between an inflammation-based prognostic score (Glasgow Prognostic Score) and changes in serum biochemical variables in patients with advanced lung and gastrointestinal cancer

Background: The Glasgow Prognostic Score (GPS), an inflammation-based prognostic score formed from standard thresholds of C reactive protein (CRP) and albumin, has prognostic value in patients with advanced cancer. Little is known about the general biochemical disturbance associated with the systemi...

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Bibliographic Details
Published in:Journal of clinical pathology 2007-06, Vol.60 (6), p.705-708
Main Authors: Brown, D J F, Milroy, R, Preston, T, McMillan, D C
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Alkaline Phosphatase - blood
Biological and medical sciences
Biomarkers, Tumor - blood
Blood platelets
Body mass index
C reactive protein
C-Reactive Protein - analysis
Cancer
Chemotherapy
CRP
Dehydrogenases
Enzymes
Female
gamma-Glutamyltransferase - blood
Gastrointestinal Neoplasms - blood
Gastrointestinal Neoplasms - complications
Glasgow Prognostic Score
GPS
Humans
Inflammation
Investigative techniques, diagnostic techniques (general aspects)
Karnofsky Performance Status
Kinases
KPS
Lung Neoplasms - blood
Lung Neoplasms - complications
Male
Medical sciences
Middle Aged
Original
Palliative care
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Patients
Permeability
Phosphatase
Pneumology
Prognosis
Proteins
Scholarships & fellowships
Serum Albumin - analysis
Severity of Illness Index
Systemic Inflammatory Response Syndrome - blood
Systemic Inflammatory Response Syndrome - etiology
Tumors of the respiratory system and mediastinum
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Summary:Background: The Glasgow Prognostic Score (GPS), an inflammation-based prognostic score formed from standard thresholds of C reactive protein (CRP) and albumin, has prognostic value in patients with advanced cancer. Little is known about the general biochemical disturbance associated with the systemic inflammatory response in cancer. Aim: To examine the relationship between the GPS and blood biochemistry in patients with advanced lung and gastrointestinal cancer. Methods: The GPS (albumin 10 mg/l = 1 combined to form a prognostic score of 0 (normal) and 1 or 2 (abnormal)) and a variety of biochemical variables were examined in patients (n = 50) with advanced lung or gastrointestinal cancer and in a healthy control group (n = 13). Results: The GPS was normal in all the controls, but abnormal in 78% of the cancer group. Serum levels of sodium, chloride, creatine kinase, zinc and vitamin D were lower in the cancer group (all p
ISSN:0021-9746
1472-4146
DOI:10.1136/jcp.2005.033217