Changes in causes of death in systemic sclerosis, 1972–2002

Background: Survival of scleroderma has changed since the renal crisis treatment has become possible. Aims: To document the changes in survival and organ system causes of mortality in systemic sclerosis (SSc) over the past 25 years in patients from a single medical centre. Methods: Consecutive patie...

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Bibliographic Details
Published in:Annals of the rheumatic diseases 2007-07, Vol.66 (7), p.940-944
Main Authors: Steen, Virginia D, Medsger, Thomas A
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Cardiovascular disease
Cause of Death
Colleges & universities
Data analysis
Extended Report
Female
gastrointestinal
Gastrointestinal Diseases - complications
Gastrointestinal Diseases - mortality
Heart attacks
Humans
Infections
Kidney Diseases - complications
Kidney Diseases - mortality
Lung diseases
Lung Diseases - complications
Lung Diseases - mortality
Male
Medical sciences
Mortality
PAH
Patients
Pennsylvania - epidemiology
Pneumology
Prospective Studies
pulmonary arterial hypertension
Pulmonary arteries
pulmonary fibrosis
Pulmonary hypertension
Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases
Respiratory system : syndromes and miscellaneous diseases
RNA polymerase
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Scleroderma
scleroderma renal crisis
Scleroderma, Systemic - complications
Scleroderma, Systemic - mortality
Sex Distribution
SRC
SSc
Survival Analysis
systemic sclerosis
Time Factors
Citations: Items that cite this one
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Summary:Background: Survival of scleroderma has changed since the renal crisis treatment has become possible. Aims: To document the changes in survival and organ system causes of mortality in systemic sclerosis (SSc) over the past 25 years in patients from a single medical centre. Methods: Consecutive patients evaluated at the University of Pittsburgh, Pittsburgh, Pennsylvania, USA between 1 January 1972 and 31 December 1996 were studied. Survival was determined in five 5-year time periods between 1972 and 1997. Causes of death included scleroderma-related (scleroderma renal crisis, pulmonary arterial hypertension, pulmonary fibrosis (PF), gastrointestinal (GI), heart and multiorgan failure) and non-scleroderma-related (cancer, atherosclerotic cardiovascular or cerebrovascular disease, infection, sudden death, other and unknown) causes. Results: The 10-year survival improved steadily from 54% to 66% during each of the time intervals. There was a significant improvement in survival for patients during 1982–91 compared with those during 1972–81 (p
ISSN:0003-4967
1468-2060
DOI:10.1136/ard.2006.066068