Left ventricular non-compaction cardiomyopathy in children: characterisation of clinical status using tissue Doppler-derived indices of left ventricular diastolic relaxation

Background: Left ventricular non-compaction (LVNC) may manifest an undulating phenotype ranging from dilated to hypertrophic appearance. It is unknown whether tissue Doppler (TD) velocities can predict adverse clinical outcomes including death and need for transplantation in children with LVNC. Meth...

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Bibliographic Details
Published in:Heart (British Cardiac Society) 2007-06, Vol.93 (6), p.676-681
Main Authors: McMahon, Colin J, Pignatelli, Ricardo H, Nagueh, Sherif F, Lee, Vei-Vei, Vaughn, William, Valdes, Santiago O, Kovalchin, John P, Lynn Jefferies, J, Dreyer, William J, Denfield, Susan W, Clunie, Sarah, Towbin, Jeffrey A, Eidem, Benjamin W
Format: Article
Language:English
Subjects:
ACE
Adolescent
angiotensin-converting enzyme
Biological and medical sciences
Cardiology. Vascular system
Cardiomyopathies - diagnostic imaging
Cardiomyopathies - mortality
Cardiomyopathies - physiopathology
Cardiomyopathies - surgery
Cardiomyopathy
Cardiovascular system
Case-Control Studies
CHF
Child
Child, Preschool
Congenital Heart Disease
congestive heart failure
DCM
Diastole
dilated cardiomyopathy
early diastolic annular velocity
Echocardiography, Doppler
Female
Flow velocity
Genotype & phenotype
HCM
Heart
Heart attacks
Heart failure
Heart Failure - etiology
Heart Transplantation
Humans
hypertrophic cardiomyopathy
Infant
Investigative techniques, diagnostic techniques (general aspects)
isovolumic relaxation time
IVRT
Kaplan-Meier Estimate
late diastolic annular velocity
left ventricular
left ventricular ejection fraction
left ventricular non-compaction cardiomyopathy
LVEF
LVNC
Male
Medical sciences
Myocarditis. Cardiomyopathies
PEP
primary end point
Prognosis
Propagation
Prospective Studies
receiver operator characteristic
ROC
ROC Curve
secondary end point
SEP
Software
Stroke Volume
Studies
systolic tissue Doppler velocity
tissue Doppler
Ultrasonic investigative techniques
Veins & arteries
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Summary:Background: Left ventricular non-compaction (LVNC) may manifest an undulating phenotype ranging from dilated to hypertrophic appearance. It is unknown whether tissue Doppler (TD) velocities can predict adverse clinical outcomes including death and need for transplantation in children with LVNC. Methods and results: 56 children (median age 4.5 years, median follow-up 26 months) with LVNC evaluated at one hospital from January 1999 to May 2004 were compared with 56 age/sex-matched controls. Children with LVNC had significantly decreased early diastolic TD velocities (Ea) at the lateral mitral (11.0 vs 17.0 cm/s) and septal (8.9 vs 11.0 cm/s) annuli compared with normal controls (p
ISSN:1355-6037
1468-201X
DOI:10.1136/hrt.2006.093880