Remote ischaemic postconditioning protects the heart during acute myocardial infarction in pigs

Background: Ischaemic preconditioning results in a reduction in ischaemic-reperfusion injury to the heart. This beneficial effect is seen both with direct local preconditioning of the myocardium and with remote preconditioning of easily accessible distant non-vital limb tissue. Ischaemic postconditi...

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Bibliographic Details
Published in:Heart (British Cardiac Society) 2007-06, Vol.93 (6), p.749-752
Main Authors: Andreka, Gyorgy, Vertesaljai, Marton, Szantho, Gergely, Font, Gusztav, Piroth, Zsolt, Fontos, Geza, Juhasz, Eszter D, Szekely, Laszlo, Szelid, Zsolt, Turner, Mark S, Ashrafian, Houman, Frenneaux, Michael P, Andreka, Peter
Format: Article
Language:English
Subjects:
Adenosine
Angioplasty
Angioplasty, Balloon, Coronary
Animals
Area Under Curve
Basic Research
Biological and medical sciences
Cardiology. Vascular system
Coronary heart disease
Coronary vessels
Creatine Kinase - blood
Female
Gangrene
Heart
Heart attacks
Ischemic Preconditioning, Myocardial - methods
Kinases
Laboratory animals
LAD
late enhancement
left anterior descending artery
left ventricule
Male
Medical sciences
Mortality
Myocardial Infarction - enzymology
Myocardial Infarction - etiology
Myocardial Infarction - pathology
Myocardial Infarction - therapy
Myocarditis. Cardiomyopathies
Myocardium - pathology
percutaneous transluminal coronary angioplasty
PTCA
Rodents
ST elevation myocardial infarction
STEMI
Sus scrofa
Veins & arteries
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Summary:Background: Ischaemic preconditioning results in a reduction in ischaemic-reperfusion injury to the heart. This beneficial effect is seen both with direct local preconditioning of the myocardium and with remote preconditioning of easily accessible distant non-vital limb tissue. Ischaemic postconditioning with a comparable sequence of brief periods of local ischaemia, when applied immediately after the ischaemic insult, confers benefits similar to preconditioning. Objective: To test the hypothesis that limb ischaemia induces remote postconditioning and hence reduces experimental myocardial infarct size in a validated swine model of acute myocardial infarction. Methods: Acute myocardial infarction was induced in 24 pigs with 90 min balloon inflations of the left anterior descending coronary artery. Remote ischaemic postconditioning was induced in 12 of the pigs by four 5 min cycles of blood pressure cuff inflation applied to the lower limb immediately after the balloon deflation. Infarct size was assessed by measuring 72 h creatinine kinase release, MRI scan and immunohistochemical analysis. Results: Area under the curve of creatinine kinase release was significantly reduced in the postconditioning group compared with the control group with a 26% reduction in the infarct size (p
ISSN:1355-6037
1468-201X
DOI:10.1136/hrt.2006.114504