Chronically recording with a multi-electrode array device in the auditory cortex of an awake ferret

It is known that anesthesia depresses neural activity and inhibits cortico-cortical interactions and cortical output. Hence, it is important to record from awake animals in order to better understand the full dynamic range of neural responses. We have developed a preparation for chronic, multi-elect...

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Bibliographic Details
Published in:Journal of neuroscience methods 2007-03, Vol.161 (1), p.101-111
Main Authors: Dobbins, Heather D., Marvit, Peter, Ji, Yadong, Depireux, Didier A.
Format: Article
Language:English
Subjects:
Acoustic Stimulation - methods
Animals
Auditory Cortex - cytology
Auditory Cortex - physiology
Awake
Chronic
Cortex
Electrodes, Implanted
Electrophysiology - instrumentation
Evoked Potentials, Auditory - physiology
Ferret
Ferrets
Multi-electrode
Wakefulness
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Summary:It is known that anesthesia depresses neural activity and inhibits cortico-cortical interactions and cortical output. Hence, it is important to record from awake animals in order to better understand the full dynamic range of neural responses. We have developed a preparation for chronic, multi-electrode physiological recording in the cortex of the awake ferret. This paper discusses several of the advantages and disadvantages of the technique as well as procedures used to overcome potential complications associated with chronic implants in the ferret. Our solutions are well suited to the special species requirements, yet are also easily generalizable to other species.
ISSN:0165-0270
1872-678X
DOI:10.1016/j.jneumeth.2006.10.013