Molecular basis for checkpoints in the CD8 T cell response: Tolerance versus activation

Abstract CD8 T cells specific for self-antigens are present in the peripheral lymphoid system and can contribute to autoimmunity or transplant rejection. Whether recognition of Ag leads to full activation, or to induction of tolerance, depends upon availability of cytokine at critical stages of the...

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Bibliographic Details
Published in:Seminars in immunology 2007-06, Vol.19 (3), p.153-161
Main Authors: Mescher, Matthew F, Agarwal, Pujya, Casey, Kerry A, Hammerbeck, Christopher D, Xiao, Zhengguo, Curtsinger, Julie M
Format: Article
Language:English
Subjects:
Activation
Allergy and Immunology
Anergy
Animals
CD28 Antigens - immunology
CD28 Antigens - physiology
CD8 T lymphocyte
Differentiation
Immune Tolerance
Immunity, Cellular - immunology
Lymphocyte Activation
Peripheral tolerance
T-Lymphocyte Subsets - immunology
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Summary:Abstract CD8 T cells specific for self-antigens are present in the peripheral lymphoid system and can contribute to autoimmunity or transplant rejection. Whether recognition of Ag leads to full activation, or to induction of tolerance, depends upon availability of cytokine at critical stages of the response. Signals provided by IL-12 and/or IFN-α/β are required for activation of naïve CD8 T cells, and IL-2 is needed to sustain and further expand the effector cells if Ag persists. These critical signaling requirements provide new insights into the factors that regulate the CD8 T cell contributions to development of autoimmunity or rejection of transplants.
ISSN:1044-5323
1096-3618
DOI:10.1016/j.smim.2007.02.007