Prosthetic valvular endocarditis due to the fungus Paecilomyces

The third reported case of prosthetic valvular endocarditis caused by the fungus Paecilomyces is presented. The clinical course of the patient is discussed. The distinctive morphology of the fungus is described, together with the histologic and cytologic features found in the excised prosthetic valv...

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Bibliographic Details
Published in:Canadian Medical Association journal 1974-11, Vol.111 (9), p.963-968
Main Authors: Haldane, E V, MacDonald, J L, Gittens, W O, Yuce, K, van Rooyen, C E
Format: Article
Language:English
Subjects:
Amphotericin B - therapeutic use
Autopsy
Brain Abscess - etiology
Brain Abscess - pathology
Candidiasis - complications
Candidiasis - microbiology
Candidiasis - pathology
Cytosine - analogs & derivatives
Cytosine - therapeutic use
Endocarditis - complications
Endocarditis - drug therapy
Endocarditis - etiology
Endocarditis - microbiology
Endocarditis - pathology
Heart Valve Prosthesis
Humans
Male
Medical Practice
Middle Aged
Mitosporic Fungi - isolation & purification
Subarachnoid Hemorrhage - etiology
Subarachnoid Hemorrhage - pathology
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Summary:The third reported case of prosthetic valvular endocarditis caused by the fungus Paecilomyces is presented. The clinical course of the patient is discussed. The distinctive morphology of the fungus is described, together with the histologic and cytologic features found in the excised prosthetic valve and in the tissues at autopsy. Prosthetic valvular endocarditis presents a serious antibiotic and surgical problem in therapy. Despite antifungal antibiotics and valve replacement this patient died as a result of metastatic cerebral microabscesses and subarachnoid hemorrhage.
ISSN:0008-4409