Specific polymorphic variation in the mitochondrial genome and increased in-hospital mortality after severe trauma

To determine whether specific genetic variations in the mtDNA that impact energy production and free-radical generation are potential new risk factors for in-hospital mortality after severe trauma. Each of the 3 mitochondrial DNA polymorphisms selected for this study (at positions 4216, 10398, 4917)...

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Bibliographic Details
Published in:Annals of surgery 2007-09, Vol.246 (3), p.406-414
Main Authors: Canter, Jeffrey A, Norris, Patrick R, Moore, Jason H, Jenkins, Judith M, Morris, John A
Format: Article
Language:English
Subjects:
Adult
Alleles
Chi-Square Distribution
DNA, Mitochondrial - genetics
Female
Genome, Human
Genotype
Hospital Mortality
Humans
Injury Severity Score
Lactates - blood
Logistic Models
Male
Middle Aged
Original
Phenotype
Polymorphism, Genetic
Prospective Studies
Risk Factors
Statistics, Nonparametric
Wounds and Injuries - mortality
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Summary:To determine whether specific genetic variations in the mtDNA that impact energy production and free-radical generation are potential new risk factors for in-hospital mortality after severe trauma. Each of the 3 mitochondrial DNA polymorphisms selected for this study (at positions 4216, 10398, 4917) alter the amino acid sequence of different key subunits of Complex I in the electron transport chain. They have been previously implicated in phenotypes involving tissues with high-energy demand, such as the brain and retina. Seven hundred forty-five consecutive patients admitted to the trauma intensive care unit at Vanderbilt University Medical Center between April 11, 2005, and February 27, 2006, were potentially eligible for this study. Under an Institutional Review Board-approved protocol (which excluded patients
ISSN:0003-4932
1528-1140
DOI:10.1097/SLA.0b013e3181469955