Identification of a high frequency of chromosomal rearrangements in the centromeric regions of prostate cancer patients

The aim of the present investigation was to study the major chromosomal aberrations (CA) like deletion, translocation, inversion and mosaic in prostate cancer patients of Tamilnadu, Southern India. Totally 45 blood samples were collected from various hospitals in Tamilnadu, Southern India. Equal num...

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Bibliographic Details
Published in:Journal of Zhejiang University. B. Science 2007-09, Vol.8 (9), p.638-646
Main Authors: Balachandar, V, Lakshman Kumar, B, Sasikala, K, Manikantan, P, Sangeetha, R, Mohana Devi, S
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biomedicine
Centromere - genetics
Chromosome Aberrations - statistics & numerical data
Comorbidity
Genetic Predisposition to Disease - epidemiology
Genetic Predisposition to Disease - genetics
Humans
India - epidemiology
Male
Medical research
Middle Aged
Prevalence
Prostate cancer
Prostatic Neoplasms - epidemiology
Prostatic Neoplasms - genetics
Risk Assessment - methods
Risk Factors
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Summary:The aim of the present investigation was to study the major chromosomal aberrations (CA) like deletion, translocation, inversion and mosaic in prostate cancer patients of Tamilnadu, Southern India. Totally 45 blood samples were collected from various hospitals in Tamilnadu, Southern India. Equal numbers of normal healthy subjects were chosen after signing a consent form. Volunteers provided blood samples (5 ml) to establish leukocyte cultures. Cytogenetic studies were performed by using Giemsa-banding technique and finally the results were ensured by spectral karyotyping (SKY) technique. In the present investigation, major CA like deletion, translocation, inversion and mosaic were identified in experimental subjects. Results showed frequent CA in chromosomes 1, 3, 5, 6, 7, 9, 13, 16, 18 and X. In comparison with experimental subjects, the control subjects exhibited very low levels of major CA (P
ISSN:1673-1581
1862-1783
DOI:10.1631/jzus.2007.B0638