Long‐term colonic hypersensitivity in adult rats induced by neonatal unpredictable vs predictable shock

Our goal was to examine the relationship between early life trauma and the development of visceral hypersensitivity in later life in irritable bowel syndrome (IBS). Rat pups underwent neonatal conditioning: (i) paired odour‐shock, where odour is a predictable shock signal, (ii) unpaired odour‐shock,...

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Bibliographic Details
Published in:Neurogastroenterology and motility 2007-09, Vol.19 (9), p.761-768
Main Authors: Tyler, K., Moriceau, S., Sullivan, R. M., Greenwood‐van Meerveld, B.
Format: Article
Language:English
Subjects:
amygdala
Animals
Animals, Newborn
colon
Conditioning, Classical
Fear - physiology
fear conditioning
Female
Hyperalgesia - physiopathology
hypersensitivity
infant trauma
irritable bowel syndrome
Irritable Bowel Syndrome - physiopathology
Male
Manometry
Odorants
predictable
Rats
Stress, Psychological - physiopathology
Time Factors
unpredictable
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Summary:Our goal was to examine the relationship between early life trauma and the development of visceral hypersensitivity in later life in irritable bowel syndrome (IBS). Rat pups underwent neonatal conditioning: (i) paired odour‐shock, where odour is a predictable shock signal, (ii) unpaired odour‐shock, where odour is an unpredictable shock signal or (iii) control odour‐only with odour presentations and handling without shock. At maturity, colorectal sensitivity was measured as a visceromotor behavioural response. In adulthood, colorectal distension (CRD) induced a pressure‐dependent increase in the number of abdominal muscle contractions all three experimental groups. However, compared to animals that had received control odour‐only presentations in infancy, there was an attenuated response to CRD in animals previously exposed to neonatal predictable shock pups and an exaggerated response in the animals previously exposed to neonatal unpredictable shock. Adult responses to CRD were altered by infant experience with shock trauma. However, depending on the context of that early life trauma, there are major differences between the long‐term effects of that early life trauma on colonic sensitivity compared to controls. These results strengthen the link between early life trauma and adult IBS, and suggest that unpredictable trauma is a critical factor for later life disorders.
ISSN:1350-1925
1365-2982
DOI:10.1111/j.1365-2982.2007.00955.x