Photosensitising potency of structural analogues of benzoporphyrin derivative (BPD) in a mouse tumour model

The in vivo characteristics of four analogues of benzoporphyrin derivative (BPD) have been investigated. Biodistribution data obtained in DBA/2J mice with BPD-MA (monoacid ring A analogue) which had been tritiated or internally labelled with 14C showed that both labelled materials acted in an essent...

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Bibliographic Details
Published in:British journal of cancer 1991-01, Vol.63 (1), p.87-93
Main Authors: Richter, AM, Waterfield, E, Jain, AK, Allison, B, Sternberg, ED, Dolphin, D, Levy, JG
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Cancer Research
Carbon Radioisotopes
Cell Survival
Dose-Response Relationship, Drug
Drug Resistance
Epidemiology
experimental-oncology
Medical sciences
Mice
Mice, Inbred Strains
Molecular Medicine
Neoplasms, Experimental - drug therapy
Neoplasms, Experimental - metabolism
Oncology
Photochemotherapy
Photoradiation therapy and photosensitizing agent
Porphyrins - pharmacokinetics
Porphyrins - pharmacology
Radiation-Sensitizing Agents - pharmacology
Tissue Distribution
Treatment with physical agents
Treatment. General aspects
Tumors
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Summary:The in vivo characteristics of four analogues of benzoporphyrin derivative (BPD) have been investigated. Biodistribution data obtained in DBA/2J mice with BPD-MA (monoacid ring A analogue) which had been tritiated or internally labelled with 14C showed that both labelled materials acted in an essentially identical manner during the period of study. Biodistribution and clearance studies showed that relative distribution in a variety of mouse tissues was similar for all BPD analogues. M1 tumour cells (rhabdomyosarcoma in DBA/2J mice) taken from tumours excised from animals treated 3 h earlier with BPD, and tested in vitro for photosensitivity provided evidence that significant levels of photosensitiser detected in tumour was both active and associated with tumour cells. The monoacid forms of BPD were found to be much more photodynamically active in this test than were the diacid analogues. The ability of the analogues to ablate tumours in mice by photodynamic therapy was also tested. Again, BPD-MA and BPD-MB proved to be measurably better than the diacid analogues. These findings are discussed in reference to structural and physical differences between the analogues.
ISSN:0007-0920
1532-1827
DOI:10.1038/bjc.1991.18