In vivo 31P nuclear magnetic resonance spectroscopy of experimental murine tumours and human tumour xenografts : effects of blood flow modification

The effect of hydralazine on tumours appears to vary depending on tumour type. Blood flow and radiation sensitivity decrease more in murine tumours than human tumour xenografts. In this study a comparison between various tumour types has been made using in vivo 31P nuclear magnetic resonance spectro...

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Bibliographic Details
Published in:British journal of cancer 1991-11, Vol.64 (5), p.862-866
Main Authors: BREMNER, J. C. M, COUNSELL, C. J. R, ADAMS, G. E, STRATFORD, I. J, WOOD, P. J, DUNN, J. F, RADDA, G. K
Format: Article
Language:English
Subjects:
Animals
Antineoplastic agents
Biological and medical sciences
Chemotherapy
Colonic Neoplasms - blood supply
Colonic Neoplasms - drug therapy
Humans
Hydralazine - pharmacology
Magnetic Resonance Spectroscopy - methods
Medical sciences
Melanoma, Experimental - blood supply
Melanoma, Experimental - drug therapy
Mice
Mice, Inbred C3H
Mice, Nude
Neoplasm Transplantation
Pharmacology. Drug treatments
Phosphorus
Regional Blood Flow - drug effects
Sarcoma, Experimental - blood supply
Sarcoma, Experimental - drug therapy
Transplantation, Heterologous
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Summary:The effect of hydralazine on tumours appears to vary depending on tumour type. Blood flow and radiation sensitivity decrease more in murine tumours than human tumour xenografts. In this study a comparison between various tumour types has been made using in vivo 31P nuclear magnetic resonance spectroscopy (NMRS) to follow the metabolic responses occurring after clamping or intravenous administration of hydralazine (5 mg kg-1). Large increases in the Pi/total phosphate ratio were found with the murine sarcomas, KHT and RIF-1 implanted into C3H/He mice. However little or no effect was seen for the two human xenografted tumours, HX118 and HT29 implanted in MFI nu/nu/01a mice. An intermediate response was observed for KHT tumours grown in nu/nu mice. All tumours showed a large response to clamping. The anaesthetic Hypnorm/Hypnovel has a great influence on the response of the tumour metabolism to hydralazine appearing to both prolong and increase the changes induced. There is evidence to support the theory that the changes in 31P spectra are related to the oxygen status of the tumours.
ISSN:0007-0920
1532-1827
DOI:10.1038/bjc.1991.414