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In vivo 31P nuclear magnetic resonance spectroscopy of experimental murine tumours and human tumour xenografts : effects of blood flow modification
The effect of hydralazine on tumours appears to vary depending on tumour type. Blood flow and radiation sensitivity decrease more in murine tumours than human tumour xenografts. In this study a comparison between various tumour types has been made using in vivo 31P nuclear magnetic resonance spectro...
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| Published in: | British journal of cancer 1991-11, Vol.64 (5), p.862-866 |
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| Main Authors: | , , , , , , |
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| container_end_page | 866 |
| container_issue | 5 |
| container_start_page | 862 |
| container_title | British journal of cancer |
| container_volume | 64 |
| creator | BREMNER, J. C. M COUNSELL, C. J. R ADAMS, G. E STRATFORD, I. J WOOD, P. J DUNN, J. F RADDA, G. K |
| description | The effect of hydralazine on tumours appears to vary depending on tumour type. Blood flow and radiation sensitivity decrease more in murine tumours than human tumour xenografts. In this study a comparison between various tumour types has been made using in vivo 31P nuclear magnetic resonance spectroscopy (NMRS) to follow the metabolic responses occurring after clamping or intravenous administration of hydralazine (5 mg kg-1). Large increases in the Pi/total phosphate ratio were found with the murine sarcomas, KHT and RIF-1 implanted into C3H/He mice. However little or no effect was seen for the two human xenografted tumours, HX118 and HT29 implanted in MFI nu/nu/01a mice. An intermediate response was observed for KHT tumours grown in nu/nu mice. All tumours showed a large response to clamping. The anaesthetic Hypnorm/Hypnovel has a great influence on the response of the tumour metabolism to hydralazine appearing to both prolong and increase the changes induced. There is evidence to support the theory that the changes in 31P spectra are related to the oxygen status of the tumours. |
| doi_str_mv | 10.1038/bjc.1991.414 |
| format | article |
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C. M ; COUNSELL, C. J. R ; ADAMS, G. E ; STRATFORD, I. J ; WOOD, P. J ; DUNN, J. F ; RADDA, G. K</creator><creatorcontrib>BREMNER, J. C. M ; COUNSELL, C. J. R ; ADAMS, G. E ; STRATFORD, I. J ; WOOD, P. J ; DUNN, J. F ; RADDA, G. K</creatorcontrib><description>The effect of hydralazine on tumours appears to vary depending on tumour type. Blood flow and radiation sensitivity decrease more in murine tumours than human tumour xenografts. In this study a comparison between various tumour types has been made using in vivo 31P nuclear magnetic resonance spectroscopy (NMRS) to follow the metabolic responses occurring after clamping or intravenous administration of hydralazine (5 mg kg-1). Large increases in the Pi/total phosphate ratio were found with the murine sarcomas, KHT and RIF-1 implanted into C3H/He mice. However little or no effect was seen for the two human xenografted tumours, HX118 and HT29 implanted in MFI nu/nu/01a mice. An intermediate response was observed for KHT tumours grown in nu/nu mice. All tumours showed a large response to clamping. The anaesthetic Hypnorm/Hypnovel has a great influence on the response of the tumour metabolism to hydralazine appearing to both prolong and increase the changes induced. There is evidence to support the theory that the changes in 31P spectra are related to the oxygen status of the tumours.</description><identifier>ISSN: 0007-0920</identifier><identifier>EISSN: 1532-1827</identifier><identifier>DOI: 10.1038/bjc.1991.414</identifier><identifier>PMID: 1931606</identifier><identifier>CODEN: BJCAAI</identifier><language>eng</language><publisher>Basingstoke: Nature Publishing Group</publisher><subject>Animals ; Antineoplastic agents ; Biological and medical sciences ; Chemotherapy ; Colonic Neoplasms - blood supply ; Colonic Neoplasms - drug therapy ; Humans ; Hydralazine - pharmacology ; Magnetic Resonance Spectroscopy - methods ; Medical sciences ; Melanoma, Experimental - blood supply ; Melanoma, Experimental - drug therapy ; Mice ; Mice, Inbred C3H ; Mice, Nude ; Neoplasm Transplantation ; Pharmacology. Drug treatments ; Phosphorus ; Regional Blood Flow - drug effects ; Sarcoma, Experimental - blood supply ; Sarcoma, Experimental - drug therapy ; Transplantation, Heterologous</subject><ispartof>British journal of cancer, 1991-11, Vol.64 (5), p.862-866</ispartof><rights>1992 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2554-5075dc72afb8ce4bf2a4c379bf35eac1eefd68bb5c8bc92d2b715782e71f4ccb3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977471/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977471/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=5060457$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1931606$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BREMNER, J. C. M</creatorcontrib><creatorcontrib>COUNSELL, C. J. R</creatorcontrib><creatorcontrib>ADAMS, G. E</creatorcontrib><creatorcontrib>STRATFORD, I. J</creatorcontrib><creatorcontrib>WOOD, P. J</creatorcontrib><creatorcontrib>DUNN, J. F</creatorcontrib><creatorcontrib>RADDA, G. K</creatorcontrib><title>In vivo 31P nuclear magnetic resonance spectroscopy of experimental murine tumours and human tumour xenografts : effects of blood flow modification</title><title>British journal of cancer</title><addtitle>Br J Cancer</addtitle><description>The effect of hydralazine on tumours appears to vary depending on tumour type. Blood flow and radiation sensitivity decrease more in murine tumours than human tumour xenografts. In this study a comparison between various tumour types has been made using in vivo 31P nuclear magnetic resonance spectroscopy (NMRS) to follow the metabolic responses occurring after clamping or intravenous administration of hydralazine (5 mg kg-1). Large increases in the Pi/total phosphate ratio were found with the murine sarcomas, KHT and RIF-1 implanted into C3H/He mice. However little or no effect was seen for the two human xenografted tumours, HX118 and HT29 implanted in MFI nu/nu/01a mice. An intermediate response was observed for KHT tumours grown in nu/nu mice. All tumours showed a large response to clamping. The anaesthetic Hypnorm/Hypnovel has a great influence on the response of the tumour metabolism to hydralazine appearing to both prolong and increase the changes induced. There is evidence to support the theory that the changes in 31P spectra are related to the oxygen status of the tumours.</description><subject>Animals</subject><subject>Antineoplastic agents</subject><subject>Biological and medical sciences</subject><subject>Chemotherapy</subject><subject>Colonic Neoplasms - blood supply</subject><subject>Colonic Neoplasms - drug therapy</subject><subject>Humans</subject><subject>Hydralazine - pharmacology</subject><subject>Magnetic Resonance Spectroscopy - methods</subject><subject>Medical sciences</subject><subject>Melanoma, Experimental - blood supply</subject><subject>Melanoma, Experimental - drug therapy</subject><subject>Mice</subject><subject>Mice, Inbred C3H</subject><subject>Mice, Nude</subject><subject>Neoplasm Transplantation</subject><subject>Pharmacology. Drug treatments</subject><subject>Phosphorus</subject><subject>Regional Blood Flow - drug effects</subject><subject>Sarcoma, Experimental - blood supply</subject><subject>Sarcoma, Experimental - drug therapy</subject><subject>Transplantation, Heterologous</subject><issn>0007-0920</issn><issn>1532-1827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><recordid>eNpVkU9vFCEYh4mxqWv15tWEg_HkrMAMy4yHJqbxT5MmetAzgXdetjQzMMLM2n6OfuGy2U21JwK_Jz94eQh5w9mas7r9aG9gzbuOrxvePCMrLmtR8Vao52TFGFMV6wR7QV7mfFO2HWvVKTnlXc03bLMi95eB7vwu0pr_pGGBAU2io9kGnD3QhDkGEwBpnhDmFDPE6Y5GR_F2wuRHDLMZ6LgkH5DOyxiXlKkJPb1eRhOOJ_QWQ9wm4-ZMP1F0rlTlfYkdYuypG-JfOsbeOw9m9jG8IifODBlfH9cz8vvrl18X36urH98uLz5fVSCkbCrJlOxBCeNsC9hYJ0wDteqsqyUa4Iiu37TWSmgtdKIXVnGpWoGKuwbA1mfk_NA7LXbEHsowyQx6KnOZdKej8fppEvy13sad5p1SjeKl4P2xIMU_C-ZZjz4DDoMJGJesleCqKGIF_HAAoXxhTugeL-FM7yXqIlHvJeoiseBv_3_YP_hgreTvjrnJYAaXiiKfHzHJNqyRqn4A9m-qcg</recordid><startdate>19911101</startdate><enddate>19911101</enddate><creator>BREMNER, J. C. M</creator><creator>COUNSELL, C. J. R</creator><creator>ADAMS, G. E</creator><creator>STRATFORD, I. J</creator><creator>WOOD, P. J</creator><creator>DUNN, J. F</creator><creator>RADDA, G. K</creator><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19911101</creationdate><title>In vivo 31P nuclear magnetic resonance spectroscopy of experimental murine tumours and human tumour xenografts : effects of blood flow modification</title><author>BREMNER, J. C. M ; COUNSELL, C. J. R ; ADAMS, G. E ; STRATFORD, I. J ; WOOD, P. J ; DUNN, J. F ; RADDA, G. 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Large increases in the Pi/total phosphate ratio were found with the murine sarcomas, KHT and RIF-1 implanted into C3H/He mice. However little or no effect was seen for the two human xenografted tumours, HX118 and HT29 implanted in MFI nu/nu/01a mice. An intermediate response was observed for KHT tumours grown in nu/nu mice. All tumours showed a large response to clamping. The anaesthetic Hypnorm/Hypnovel has a great influence on the response of the tumour metabolism to hydralazine appearing to both prolong and increase the changes induced. There is evidence to support the theory that the changes in 31P spectra are related to the oxygen status of the tumours.</abstract><cop>Basingstoke</cop><pub>Nature Publishing Group</pub><pmid>1931606</pmid><doi>10.1038/bjc.1991.414</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | British journal of cancer, 1991-11, Vol.64 (5), p.862-866 |
| issn | 0007-0920 1532-1827 |
| language | eng |
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| source | PubMed Central |
| subjects | Animals Antineoplastic agents Biological and medical sciences Chemotherapy Colonic Neoplasms - blood supply Colonic Neoplasms - drug therapy Humans Hydralazine - pharmacology Magnetic Resonance Spectroscopy - methods Medical sciences Melanoma, Experimental - blood supply Melanoma, Experimental - drug therapy Mice Mice, Inbred C3H Mice, Nude Neoplasm Transplantation Pharmacology. Drug treatments Phosphorus Regional Blood Flow - drug effects Sarcoma, Experimental - blood supply Sarcoma, Experimental - drug therapy Transplantation, Heterologous |
| title | In vivo 31P nuclear magnetic resonance spectroscopy of experimental murine tumours and human tumour xenografts : effects of blood flow modification |
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