Prognostic value of serum thymidine kinase, tissue polypeptide antigen and neuron specific enolase in patients with small cell lung cancer

In a group of seventy patients with small cell lung cancer the prognostic value of serum tumour markers was determined. Thymidine kinase (TK), tissue polypeptide antigen (TPA) and lactate dehydrogenase (LDH) but not neuron specific enolase (NSE) correlated significantly with survival. Since all mark...

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Bibliographic Details
Published in:British journal of cancer 1991-08, Vol.64 (2), p.369-372
Main Authors: VAN DER GAAST, A, VAN PUTTEN, W. L. J, OOSTEROM, R, COZIJNSEN, M, HOEKSTRA, R, SPLINTER, T. A. W
Format: Article
Language:English
Subjects:
Adult
Aged
Biological and medical sciences
Carcinoma, Small Cell - metabolism
Female
Humans
Lung Neoplasms - metabolism
Male
Medical sciences
Middle Aged
Peptides - metabolism
Phosphopyruvate Hydratase - blood
Pneumology
Prognosis
Thymidine Kinase - blood
Tissue Polypeptide Antigen
Tumors of the respiratory system and mediastinum
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Summary:In a group of seventy patients with small cell lung cancer the prognostic value of serum tumour markers was determined. Thymidine kinase (TK), tissue polypeptide antigen (TPA) and lactate dehydrogenase (LDH) but not neuron specific enolase (NSE) correlated significantly with survival. Since all markers were strongly interrelated with each other and with the extent of disease, the combined determination of TK, TPA and LDH or the combination of disease extent and a marker yielded no more prognostic information than a single measurement of one of these variables.
ISSN:0007-0920
1532-1827
DOI:10.1038/bjc.1991.309