Regional delivery of microspheres to liver metastases: the effects of particle size and concentration on intrahepatic distribution

There is increasing interest in the use of microspheres, loaded with chemotherapeutic agents, for regional therapy to hepatic metastases. It is necessary to deliver these particles predominately to tumour rather than to normal liver. This study investigates factors influencing the distribution of re...

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Bibliographic Details
Published in:British journal of cancer 1991-12, Vol.64 (6), p.1031-1034
Main Authors: Anderson, JH, Angerson, WJ, Willmott, N, Kerr, DJ, McArdle, CS, Cooke, TG
Format: Article
Language:English
Subjects:
Albumins - administration & dosage
Albumins - pharmacokinetics
Animals
Antineoplastic agents
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Cancer Research
Drug Resistance
Epidemiology
experimental-oncology
General aspects
Liver Neoplasms - metabolism
Liver Neoplasms - secondary
Male
Medical sciences
Microspheres
Molecular Medicine
Neoplasm Metastasis
Oncology
Pharmacology. Drug treatments
Rats
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Summary:There is increasing interest in the use of microspheres, loaded with chemotherapeutic agents, for regional therapy to hepatic metastases. It is necessary to deliver these particles predominately to tumour rather than to normal liver. This study investigates factors influencing the distribution of regionally injected microspheres. Discreet tumour was induced in rats by subcapsular hepatic inoculations of HSN cells. At 20 days, 12.5 microns, 25 microns or 40 microns diameter, radiolabelled albumin microspheres were administered, in various concentrations, via the gastroduodenal artery. Tumour to normal liver microsphere distribution ratios were determined and median values ranged from 0.1 (0.2 mg ml-1 12.5 microns microspheres) to 1.8 (20 mg ml 40 microns microspheres). Concentrated suspensions (20 mg ml-1) of large microspheres (40 microns) produced the most favourable tumour to normal liver distribution ratios. These results not only have implications for the therapeutic administration of microspheres but also for their use in blood-flow studies.
ISSN:0007-0920
1532-1827
DOI:10.1038/bjc.1991.459