Uptake of 11C-methionine in breast cancer studied by PET. An association with the size of S-phase fraction

L-[methyl-11-C]methionine (11C-methionine) uptake of seven primary breast cancers, four soft tissue metastases of breast cancer, and three other breast lesions was studied by positron emission tomography (PET). 11C-methionine accumulation was assessed by calculating the standardised uptake value (SU...

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Bibliographic Details
Published in:British journal of cancer 1991-12, Vol.64 (6), p.1121-1124
Main Authors: LESKINEN-KALLIO, S, NAGREN, K, LEHIKOINEN, P, UROTSALAINEN, U, JOENSUU, H
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Breast Neoplasms - diagnostic imaging
Breast Neoplasms - metabolism
Breast Neoplasms - pathology
Carbon Isotopes
Carcinoma, Intraductal, Noninfiltrating - diagnostic imaging
Carcinoma, Intraductal, Noninfiltrating - metabolism
Carcinoma, Intraductal, Noninfiltrating - pathology
Endocrine glands. Genital system. Mammary gland
Humans
Investigative techniques, diagnostic techniques (general aspects)
Medical sciences
Methionine - metabolism
Middle Aged
Neoplasm Metastasis
Radionuclide investigations
S Phase
Tomography, Emission-Computed
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Summary:L-[methyl-11-C]methionine (11C-methionine) uptake of seven primary breast cancers, four soft tissue metastases of breast cancer, and three other breast lesions was studied by positron emission tomography (PET). 11C-methionine accumulation was assessed by calculating the standardised uptake value (SUV). The mean SUV for breast cancer was 8.5 +/- 3.3 (s.d.), while the maximal uptake in the liver was 12.4 +/- 1.6, in the bone marrow 5.8 +/- 0.7, and in the myocardium 3.4 +/- 0.6. All eight malignant tumours larger than 30 mm in diameter accumulated clearly 11C-methionine, whereas none of the three smaller cancers (from 12 to 15 mm in diameter) were visualised. Strong uptake of 11C-methionine was associated with a large S-phase fraction (SPF) measured with flow cytometry (r = 0.77, P = 0.01), and the non-visualised cancers had all a small SPF (less than 5.5%). One benign tumour (an abscess) accumulated slightly 11C-methionine. The results indicate that both primary and metastatic breast cancer can be effectively imaged with 11C-methionine by PET, and that the accumulation of 11C-methionine may correlate with the proliferation rate of breast carcinoma.
ISSN:0007-0920
1532-1827
DOI:10.1038/bjc.1991.475