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Capsaicin inhalation in man and the effects of sodium cromoglycate
1 The inhalation of capsaicin for 1 min, delivered as an aerosol by nebulising solutions of capsaicin at concentrations of 2–65 μmol l−1, caused dose‐dependent coughing in normal volunteers and subjects with mild asthma. Capsaicin did not cause a feeling of breathlessness, and had no effect on force...
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| Published in: | British journal of pharmacology 1984-01, Vol.81 (1), p.113-117 |
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| Main Authors: | , |
| Format: | Article |
| Language: | English |
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| cites | cdi_FETCH-LOGICAL-c6300-aee8617caedd80c95a8203014313a047a4e9eabd0fd52a9b471597f8ff33a1523 |
| container_end_page | 117 |
| container_issue | 1 |
| container_start_page | 113 |
| container_title | British journal of pharmacology |
| container_volume | 81 |
| creator | Collier, J.G. Fuller, R.W. |
| description | 1
The inhalation of capsaicin for 1 min, delivered as an aerosol by nebulising solutions of capsaicin at concentrations of 2–65 μmol l−1, caused dose‐dependent coughing in normal volunteers and subjects with mild asthma. Capsaicin did not cause a feeling of breathlessness, and had no effect on forced expiratory volume in 1 s (FEV1) measured at the 1st, 5th and 9th min after the challenge was completed.
2
Coughing started within seconds of applying the face mask, continued throughout the minute of capsaicin inhalation, and stopped within seconds of the mask being removed. In any one subject the number of coughs was reproducible when repeated on the same day or after an interval of several days.
3
Experiments using local anaesthesia applied to the buccal mucosa or larynx indicated that the cough was caused by the stimulation of capsaicin‐sensitive nerve terminals situated in the larynx.
4
Cough response was not altered by the prior inhalation of sodium cromoglycate. |
| doi_str_mv | 10.1111/j.1476-5381.1984.tb10750.x |
| format | article |
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The inhalation of capsaicin for 1 min, delivered as an aerosol by nebulising solutions of capsaicin at concentrations of 2–65 μmol l−1, caused dose‐dependent coughing in normal volunteers and subjects with mild asthma. Capsaicin did not cause a feeling of breathlessness, and had no effect on forced expiratory volume in 1 s (FEV1) measured at the 1st, 5th and 9th min after the challenge was completed.
2
Coughing started within seconds of applying the face mask, continued throughout the minute of capsaicin inhalation, and stopped within seconds of the mask being removed. In any one subject the number of coughs was reproducible when repeated on the same day or after an interval of several days.
3
Experiments using local anaesthesia applied to the buccal mucosa or larynx indicated that the cough was caused by the stimulation of capsaicin‐sensitive nerve terminals situated in the larynx.
4
Cough response was not altered by the prior inhalation of sodium cromoglycate.</description><identifier>ISSN: 0007-1188</identifier><identifier>EISSN: 1476-5381</identifier><identifier>DOI: 10.1111/j.1476-5381.1984.tb10750.x</identifier><identifier>PMID: 6423016</identifier><identifier>CODEN: BJPCBM</identifier><language>eng</language><publisher>Oxford, UK: Blackwell Publishing Ltd</publisher><subject>Aerosols ; Anesthesia, Local ; Biological and medical sciences ; Capsaicin - administration & dosage ; Capsaicin - antagonists & inhibitors ; Capsaicin - pharmacology ; Cough - chemically induced ; Cough - physiopathology ; Cromolyn Sodium - administration & dosage ; Cromolyn Sodium - pharmacology ; Forced Expiratory Volume ; Heart Rate - drug effects ; Histamine and antagonists. Allergy ; Humans ; Medical sciences ; Pharmacology. Drug treatments</subject><ispartof>British journal of pharmacology, 1984-01, Vol.81 (1), p.113-117</ispartof><rights>1984 British Pharmacological Society</rights><rights>1985 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c6300-aee8617caedd80c95a8203014313a047a4e9eabd0fd52a9b471597f8ff33a1523</citedby><cites>FETCH-LOGICAL-c6300-aee8617caedd80c95a8203014313a047a4e9eabd0fd52a9b471597f8ff33a1523</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1986941/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1986941/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,4024,27923,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=8860848$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6423016$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Collier, J.G.</creatorcontrib><creatorcontrib>Fuller, R.W.</creatorcontrib><title>Capsaicin inhalation in man and the effects of sodium cromoglycate</title><title>British journal of pharmacology</title><addtitle>Br J Pharmacol</addtitle><description>1
The inhalation of capsaicin for 1 min, delivered as an aerosol by nebulising solutions of capsaicin at concentrations of 2–65 μmol l−1, caused dose‐dependent coughing in normal volunteers and subjects with mild asthma. Capsaicin did not cause a feeling of breathlessness, and had no effect on forced expiratory volume in 1 s (FEV1) measured at the 1st, 5th and 9th min after the challenge was completed.
2
Coughing started within seconds of applying the face mask, continued throughout the minute of capsaicin inhalation, and stopped within seconds of the mask being removed. In any one subject the number of coughs was reproducible when repeated on the same day or after an interval of several days.
3
Experiments using local anaesthesia applied to the buccal mucosa or larynx indicated that the cough was caused by the stimulation of capsaicin‐sensitive nerve terminals situated in the larynx.
4
Cough response was not altered by the prior inhalation of sodium cromoglycate.</description><subject>Aerosols</subject><subject>Anesthesia, Local</subject><subject>Biological and medical sciences</subject><subject>Capsaicin - administration & dosage</subject><subject>Capsaicin - antagonists & inhibitors</subject><subject>Capsaicin - pharmacology</subject><subject>Cough - chemically induced</subject><subject>Cough - physiopathology</subject><subject>Cromolyn Sodium - administration & dosage</subject><subject>Cromolyn Sodium - pharmacology</subject><subject>Forced Expiratory Volume</subject><subject>Heart Rate - drug effects</subject><subject>Histamine and antagonists. Allergy</subject><subject>Humans</subject><subject>Medical sciences</subject><subject>Pharmacology. Drug treatments</subject><issn>0007-1188</issn><issn>1476-5381</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1984</creationdate><recordtype>article</recordtype><recordid>eNqVUcFu2zAMFYYWXdrtEwYYQ7GbPSqSbXmHYUvQrgUKdIftLDAy1Siwrcxy1ubvKzdGsB3LCwm8x6enR8Y-csh4rM-bjMuySHOheMYrJbNhxaHMIXt6w2ZH6ITNAKBMOVfqLTsPYQMQwTI_Y2eFnAvgxYwtlrgN6IzrEtetscHB-XFMWuwS7OpkWFNC1pIZQuJtEnztdm1iet_6h2ZvcKB37NRiE-j91C_Y7-urX8ub9O7-x-3y-11qCgGQIpEqeGmQ6lqBqXJUc4gmpOACQZYoqSJc1WDrfI7VSpY8r0qrrBUCeT4XF-zrQXe7W7VUG-qGHhu97V2L_V57dPp_pHNr_eD_6hhRUUkeBT5NAr3_s6Mw6NYFQ02DHfld0FxUQuayiMQvB2L8Zgg92eMjHPR4Ab3RY8x6jHmUl3q6gH6Kyx_-tXlcnSKP-OWEYzDY2B4748KRplQBSqpI-3agPbqG9q8woBc_b15G8QwvHKQ5</recordid><startdate>198401</startdate><enddate>198401</enddate><creator>Collier, J.G.</creator><creator>Fuller, R.W.</creator><general>Blackwell Publishing Ltd</general><general>Nature Publishing</general><general>Nature Publishing Group</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>5PM</scope></search><sort><creationdate>198401</creationdate><title>Capsaicin inhalation in man and the effects of sodium cromoglycate</title><author>Collier, J.G. ; Fuller, R.W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c6300-aee8617caedd80c95a8203014313a047a4e9eabd0fd52a9b471597f8ff33a1523</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1984</creationdate><topic>Aerosols</topic><topic>Anesthesia, Local</topic><topic>Biological and medical sciences</topic><topic>Capsaicin - administration & dosage</topic><topic>Capsaicin - antagonists & inhibitors</topic><topic>Capsaicin - pharmacology</topic><topic>Cough - chemically induced</topic><topic>Cough - physiopathology</topic><topic>Cromolyn Sodium - administration & dosage</topic><topic>Cromolyn Sodium - pharmacology</topic><topic>Forced Expiratory Volume</topic><topic>Heart Rate - drug effects</topic><topic>Histamine and antagonists. Allergy</topic><topic>Humans</topic><topic>Medical sciences</topic><topic>Pharmacology. Drug treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Collier, J.G.</creatorcontrib><creatorcontrib>Fuller, R.W.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Collier, J.G.</au><au>Fuller, R.W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Capsaicin inhalation in man and the effects of sodium cromoglycate</atitle><jtitle>British journal of pharmacology</jtitle><addtitle>Br J Pharmacol</addtitle><date>1984-01</date><risdate>1984</risdate><volume>81</volume><issue>1</issue><spage>113</spage><epage>117</epage><pages>113-117</pages><issn>0007-1188</issn><eissn>1476-5381</eissn><coden>BJPCBM</coden><abstract>1
The inhalation of capsaicin for 1 min, delivered as an aerosol by nebulising solutions of capsaicin at concentrations of 2–65 μmol l−1, caused dose‐dependent coughing in normal volunteers and subjects with mild asthma. Capsaicin did not cause a feeling of breathlessness, and had no effect on forced expiratory volume in 1 s (FEV1) measured at the 1st, 5th and 9th min after the challenge was completed.
2
Coughing started within seconds of applying the face mask, continued throughout the minute of capsaicin inhalation, and stopped within seconds of the mask being removed. In any one subject the number of coughs was reproducible when repeated on the same day or after an interval of several days.
3
Experiments using local anaesthesia applied to the buccal mucosa or larynx indicated that the cough was caused by the stimulation of capsaicin‐sensitive nerve terminals situated in the larynx.
4
Cough response was not altered by the prior inhalation of sodium cromoglycate.</abstract><cop>Oxford, UK</cop><pub>Blackwell Publishing Ltd</pub><pmid>6423016</pmid><doi>10.1111/j.1476-5381.1984.tb10750.x</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-1188 |
| ispartof | British journal of pharmacology, 1984-01, Vol.81 (1), p.113-117 |
| issn | 0007-1188 1476-5381 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_1986941 |
| source | Open Access: PubMed Central |
| subjects | Aerosols Anesthesia, Local Biological and medical sciences Capsaicin - administration & dosage Capsaicin - antagonists & inhibitors Capsaicin - pharmacology Cough - chemically induced Cough - physiopathology Cromolyn Sodium - administration & dosage Cromolyn Sodium - pharmacology Forced Expiratory Volume Heart Rate - drug effects Histamine and antagonists. Allergy Humans Medical sciences Pharmacology. Drug treatments |
| title | Capsaicin inhalation in man and the effects of sodium cromoglycate |
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