Adenosine deaminase antagonizes inhibitory responses to adenosine and non‐adrenergic, non‐cholinergic inhibitory nerve stimulation in isolated preparations of guinea‐pig trachea

In guinea‐pig isolated tracheal tube preparations treated with dipyridamole, adenosine deaminase antagonized inhibitory responses to adenosine and non‐adrenergic, non‐cholinergic nerve stimulation. Inhibitory responses to vasoactive intestinal peptide (VIP) were unaffected and hyoscine‐sensitive exc...

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Bibliographic Details
Published in:British journal of pharmacology 1984-10, Vol.83 (2), p.323-325
Main Author: Satchell, D.G.
Format: Article
Language:English
Subjects:
Adenosine - antagonists & inhibitors
Adenosine - pharmacology
Adenosine Deaminase - pharmacology
Air breathing
Animals
Biological and medical sciences
Dipyridamole - pharmacology
Electric Stimulation
Female
Fundamental and applied biological sciences. Psychology
Guanethidine - pharmacology
Guinea Pigs
In Vitro Techniques
Male
Neurons - drug effects
Nucleoside Deaminases - pharmacology
Respiratory system: anatomy, metabolism, gas exchange, ventilatory mechanics, respiratory hemodynamics
Scopolamine - pharmacology
Trachea - innervation
Vertebrates: respiratory system
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Summary:In guinea‐pig isolated tracheal tube preparations treated with dipyridamole, adenosine deaminase antagonized inhibitory responses to adenosine and non‐adrenergic, non‐cholinergic nerve stimulation. Inhibitory responses to vasoactive intestinal peptide (VIP) were unaffected and hyoscine‐sensitive excitatory responses to field stimulation were not reduced. The evidence supports a role of adenosine as an inhibitory neurotransmitter in non‐adrenergic, non‐cholinergic nerves in trachea.
ISSN:0007-1188
1476-5381
DOI:10.1111/j.1476-5381.1984.tb16490.x