APOC3 Promoter Polymorphisms C-482T and T-455C Are Associated with the Metabolic Syndrome

Background Despite the growing epidemic of the metabolic syndrome (MetS), few studies have evaluated genetic polymorphisms associated with the MetS phenotype. One candidate, APOC3, modulates lipid and lipoprotein metabolism and the promoter polymorphisms C-482T/T-455C are associated with loss of ins...

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Bibliographic Details
Published in:Archives of medical research 2007-05, Vol.38 (4), p.444-451
Main Authors: Miller, Michael, Rhyne, Jeffrey, Chen, Hegang, Beach, Valerie, Ericson, Richard, Luthra, Kalpana, Dwivedi, Manjari, Misra, Anoop
Format: Article
Language:English
Subjects:
Adult
Apolipoprotein C-III - genetics
Female
Genetic Predisposition to Disease
Humans
Internal Medicine
Male
Metabolic Syndrome - genetics
Middle Aged
Polymorphism, Genetic
Promoter Regions, Genetic - genetics
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Summary:Background Despite the growing epidemic of the metabolic syndrome (MetS), few studies have evaluated genetic polymorphisms associated with the MetS phenotype. One candidate, APOC3, modulates lipid and lipoprotein metabolism and the promoter polymorphisms C-482T/T-455C are associated with loss of insulin downregulation. Methods One hundred twenty two consecutive MetS cases were matched by age, sex and race in a 1:1 case-control design to evaluate the prevalence of common polymorphisms in the following candidate genes: APOC3, APOE, B3AR, FABP2, GNB3, LPL , and PPARα and PPARγ. Results Compared to controls, MetS subjects exhibited a greater prevalence of APOC3 promoter polymorphisms. Specifically, the frequency of the variant C-482T and T-455C alleles was 70.5 and 81.9% of cases compared to 43.4 and 54.1% in controls, respectively ( p
ISSN:0188-4409
DOI:10.1016/j.arcmed.2006.10.013