Long-term Anticoagulant Therapy after Myocardial Infarction in Women

A multicentre trial from five medical departments in Oslo has been carried out to determine the value in women patients of one year's long-term anticoagulant therapy. Follow-up long-term laboratory control and anticoagulant dosage were performed at one centre (the Rikshospitalet). One hundred a...

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Bibliographic Details
Published in:BMJ 1968-09, Vol.3 (5618), p.571-574
Main Authors: Borchgrevink, Chr. F., Bjerkelund, Chr, Abrahamsen, A. M., Bay, G., Borgen, P., Grande, B., Helle, I., Kjörstad, H., Petersen, A. M., Rörvik, T., Thorsen, R., Ödegaard, A.
Format: Article
Language:English
Subjects:
Aged
Angina pectoris
Anticoagulants
Anticoagulants - adverse effects
Anticoagulants - therapeutic use
Bleeding
Blood Coagulation Tests
Clinical Trials as Topic
Coagulants
Control groups
Dicumarol - therapeutic use
Female
Follow-Up Studies
Hospital admissions
Humans
Middle Aged
Mortality
Myocardial infarction
Myocardial Infarction - drug therapy
Myocardial Infarction - mortality
Papers and Originals
Phenindione - therapeutic use
Prothrombin time
Thrombosis
Time Factors
Warfarin - therapeutic use
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Description
Summary:A multicentre trial from five medical departments in Oslo has been carried out to determine the value in women patients of one year's long-term anticoagulant therapy. Follow-up long-term laboratory control and anticoagulant dosage were performed at one centre (the Rikshospitalet). One hundred and fifty-nine patients were assigned randomly into two similar well-matched groups (control and treatment). Dosage was controlled by Thrombotest, aiming at 10–20% levels, and 50% of the tests were less than 14%. Compared with the control group, the treatment group showed a significant reduction in mortality and in reinfarction rate. No serious bleeding complications occurred. It is concluded that women benefit as much as men from long-term anticoagulant therapy.
ISSN:0007-1447
0959-8138
1468-5833
DOI:10.1136/bmj.3.5618.571