Long-term Anticoagulant Therapy after Myocardial Infarction in Women

A multicentre trial from five medical departments in Oslo has been carried out to determine the value in women patients of one year's long-term anticoagulant therapy. Follow-up long-term laboratory control and anticoagulant dosage were performed at one centre (the Rikshospitalet). One hundred a...

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Published in:BMJ 1968-09, Vol.3 (5618), p.571-574
Main Authors: Borchgrevink, Chr. F., Bjerkelund, Chr, Abrahamsen, A. M., Bay, G., Borgen, P., Grande, B., Helle, I., Kjörstad, H., Petersen, A. M., Rörvik, T., Thorsen, R., Ödegaard, A.
Format: Article
Language:English
Subjects:
Aged
Angina pectoris
Anticoagulants
Anticoagulants - adverse effects
Anticoagulants - therapeutic use
Bleeding
Blood Coagulation Tests
Clinical Trials as Topic
Coagulants
Control groups
Dicumarol - therapeutic use
Female
Follow-Up Studies
Hospital admissions
Humans
Middle Aged
Mortality
Myocardial infarction
Myocardial Infarction - drug therapy
Myocardial Infarction - mortality
Papers and Originals
Phenindione - therapeutic use
Prothrombin time
Thrombosis
Time Factors
Warfarin - therapeutic use
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container_end_page 574
container_issue 5618
container_start_page 571
container_title BMJ
container_volume 3
creator Borchgrevink, Chr. F.
Bjerkelund, Chr
Abrahamsen, A. M.
Bay, G.
Borgen, P.
Grande, B.
Helle, I.
Kjörstad, H.
Petersen, A. M.
Rörvik, T.
Thorsen, R.
Ödegaard, A.
description A multicentre trial from five medical departments in Oslo has been carried out to determine the value in women patients of one year's long-term anticoagulant therapy. Follow-up long-term laboratory control and anticoagulant dosage were performed at one centre (the Rikshospitalet). One hundred and fifty-nine patients were assigned randomly into two similar well-matched groups (control and treatment). Dosage was controlled by Thrombotest, aiming at 10–20% levels, and 50% of the tests were less than 14%. Compared with the control group, the treatment group showed a significant reduction in mortality and in reinfarction rate. No serious bleeding complications occurred. It is concluded that women benefit as much as men from long-term anticoagulant therapy.
doi_str_mv 10.1136/bmj.3.5618.571
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identifier ISSN: 0007-1447
ispartof BMJ, 1968-09, Vol.3 (5618), p.571-574
issn 0007-1447
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source PubMed (Medline); BMJ
subjects Aged
Angina pectoris
Anticoagulants
Anticoagulants - adverse effects
Anticoagulants - therapeutic use
Bleeding
Blood Coagulation Tests
Clinical Trials as Topic
Coagulants
Control groups
Dicumarol - therapeutic use
Female
Follow-Up Studies
Hospital admissions
Humans
Middle Aged
Mortality
Myocardial infarction
Myocardial Infarction - drug therapy
Myocardial Infarction - mortality
Papers and Originals
Phenindione - therapeutic use
Prothrombin time
Thrombosis
Time Factors
Warfarin - therapeutic use
title Long-term Anticoagulant Therapy after Myocardial Infarction in Women
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