Reduced circulating levels of angiotensin-(1–7) in systemic sclerosis: a new pathway in the dysregulation of endothelial-dependent vascular tone control

Objective:Systemic sclerosis (SSc) impairs endothelium-dependent vasodilatation. Among angiotensin I (Ang I)-derived compounds, vasoconstrictor angiotensin II (Ang II) and vasodilator angiotensin-(1–7) (Ang-(1–7)), cleaved from ACE and neutral endopeptidase (NEP) 24.11, respectively, play an importa...

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Published in:Annals of the rheumatic diseases 2007-10, Vol.66 (10), p.1305-1310
Main Authors: Pignone, Alberto, Rosso, Angela Del, Brosnihan, K Bridget, Perfetto, Federico, Livi, Riccardo, Fiori, Ginevra, Guiducci, Serena, Cinelli, Marina, Rogai, Veronica, Tempestini, Alessio, Bartoli, Francesca, Generini, Sergio, Ferrario, Carlos M, Cerinic, Marco Matucci
Format: Article
Language:English
Subjects:
Angiogenesis
angiotensin (1–7)
angiotensin converting enzyme
Angiotensin I - blood
Angiotensin II - blood
Antihypertensive Agents - blood
Biological and medical sciences
Cell growth
Colleges & universities
Endothelium
Epoprostenol - blood
Extended Report
Female
Fibroblasts
Homeostasis
Humans
Kidneys
Male
Medical sciences
Middle Aged
Neprilysin - blood
neutral endopeptidase
Nitrates
Nitric Oxide - blood
Peptide Fragments - blood
Peptides
Peptidyl-Dipeptidase A - blood
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
Scleroderma, Systemic - blood
Smooth muscle
systemic sclerosis
Vasoconstrictor Agents - blood
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Summary:Objective:Systemic sclerosis (SSc) impairs endothelium-dependent vasodilatation. Among angiotensin I (Ang I)-derived compounds, vasoconstrictor angiotensin II (Ang II) and vasodilator angiotensin-(1–7) (Ang-(1–7)), cleaved from ACE and neutral endopeptidase (NEP) 24.11, respectively, play an important role in vascular tone regulation. Ang-(1–7) may act independently or by activating other vasodilating molecules, such as nitric oxide (NO) or prostaglandin I2 (PGI2). Our aim was to assess, in patients with SSc, circulating levels of Ang I, Ang II and Ang-(1–7), with their metabolising enzymes ACE and NEP, and levels of NO and PGI2, and to correlate them to the main characteristics of SSc.Methods:Levels of Ang I, Ang II, Ang-(1–7), NEP, ACE, NO and PGI2 were measured in 32 patients with SSc, who were also assessed for humoral and clinical characteristics, and 55 controls.Results:Plasma Ang I, Ang II and Ang-(1–7) levels were lower in patients with SSc than in controls (p
ISSN:0003-4967
1468-2060
DOI:10.1136/ard.2006.064493