Dynamics of poly(ethylene glycol)-tethered, pH responsive networks

Smart biomaterials composed of pH responsive polymers, poly((meth)acrylic acid), were synthesized using a precipitation polymerization technique. The microparticles were grafted with poly(ethylene glycol) (PEG) chains that are capable of complexing with the hydroxyl groups of the polyacid and interp...

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Bibliographic Details
Published in:Polymer (Guilford) 2007-08, Vol.48 (17), p.5042-5048
Main Authors: Thomas, J. Brock, Tingsanchali, Joseph H., Rosales, Adrianne M., Creecy, Courtney M., McGinity, James W., Peppas, Nicholas A.
Format: Article
Language:English
Subjects:
Applied sciences
Biological and medical sciences
Copolymerization
Exact sciences and technology
General pharmacology
Medical sciences
Organic polymers
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Physicochemistry of polymers
Poly(acrylic acid)
Poly(ethylene glycol)
Poly(methacrylic acid)
Preparation, kinetics, thermodynamics, mechanism and catalysts
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Summary:Smart biomaterials composed of pH responsive polymers, poly((meth)acrylic acid), were synthesized using a precipitation polymerization technique. The microparticles were grafted with poly(ethylene glycol) (PEG) chains that are capable of complexing with the hydroxyl groups of the polyacid and interpenetrating into the mucus gel layer upon entry into the small intestine. Upon introduction of an alkaline solution, these materials imbibe a significant amount of water and create a highly viscous suspension. These materials have the necessary physicochemical properties to serve as mucoadhesive controlled release drug carriers for the oral delivery of drugs.
ISSN:0032-3861
1873-2291
DOI:10.1016/j.polymer.2007.06.035