Performance of the 24-2-5 frequency doubling technology screening test: a prospective case study

• Published in: British journal of ophthalmology 2007-10, Vol.91 (10), p.1345-1349
• Main Authors: Spry, P G D, Hussin, H M, Sparrow, J M
• Format: Article
• Language: English
• Subjects: Biological and medical sciences; Extended Report; Female; Glaucoma - diagnosis; Humans; Male; Medical sciences; Middle Aged; Miscellaneous; Ophthalmology; Prospective Studies; Reproducibility of Results; ROC Curve; Sensitivity and Specificity; Sensory Thresholds; Time Factors; Vision Tests - methods; Visual Field Tests - methods; Visual Fields
• ISSN: 0007-1161; 1468-2079
• DOI: 10.1136/bjo.2007.115436

Aim:To evaluate the performance of the frequency doubling technology (FDT) 24-2-5 screening test by comparison with the established N-30-5 FDT screening test for detection of glaucoma.Method:A prospective random sample of individuals referred for possible glaucoma were tested with FDT screening tests 24-2-5 and N-30-5 using the Humphrey Matrix perimeter in addition to standard clinical examination relevant to glaucoma detection. Discriminatory power, reliability and test time of these tests were assessed and compared. The case definition for glaucoma was made by patient according to the established clinical diagnosis.Results:Of 63 referred eligible individuals, 53 (84%) were recruited. Sensitivity and specificity for the N-30-5 screening test was 78 and 85% respectively, compared with 83% and 75% for the 24-2-5 with areas under a receiver operator characteristic curve being 0.87 and 0.92. Differences between these indices were not statistically significant. For a specificity of 95%, sensitivity values were 76% and 56% for the 24-2-5 and N-30-5 respectively. Mean (standard deviation) test duration for the FDT 24-2-5 and N-30-5 screening tests were 111 (13) and 39 (10) seconds respectively (p