Inhibitors of adriamycin-induced histamine release in vitro limit adriamycin cardiotoxicity in vivo

The activity of theophylline and disodium cromoglycate was tested on adriamycin-induced histamine release in vitro and on adriamycin cardiotoxicity in vivo . Both substances significantly inhibited the release of histamine induced by 100 micrograms ml-1 of adriamycin on rat peritoneal cells and prod...

Full description

Saved in:
Bibliographic Details
Published in:British journal of cancer 1986-11, Vol.54 (5), p.743-748
Main Authors: Klugmann, F B, Decorti, G, Candussio, L, Grill, V, Mallardi, F, Baldini, L
Format: Article
Language:English
Subjects:
Acetylcysteine - pharmacology
Animals
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Cancer Research
Cardiomyopathies - chemically induced
Cardiomyopathies - prevention & control
Cromolyn Sodium - pharmacology
Dose-Response Relationship, Drug
Doxorubicin - adverse effects
Doxorubicin - antagonists & inhibitors
Drug Resistance
Drug toxicity and drugs side effects treatment
Epidemiology
Histamine Release - drug effects
Male
Mast Cells - drug effects
Medical sciences
Molecular Medicine
Oncology
original-article
p-Methoxy-N-methylphenethylamine - antagonists & inhibitors
Pharmacology. Drug treatments
Rats
Rats, Inbred Strains
Theophylline - pharmacology
Toxicity: cardiovascular system
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The activity of theophylline and disodium cromoglycate was tested on adriamycin-induced histamine release in vitro and on adriamycin cardiotoxicity in vivo . Both substances significantly inhibited the release of histamine induced by 100 micrograms ml-1 of adriamycin on rat peritoneal cells and produced significant protection against adriamycin-mediated acute and chronic cardiotoxicity in mice. N-acetylcysteine, a free radical scavenger, successfully used in the prevention of the cardiomyopathy, was also found to be an inhibitor of histamine release induced by adriamycin and compound 48/80 on rat peritoneal cells. This study further supports the hypothesis that the release of histamine may be involved in the pathogenesis of anthracycline cardiotoxicity.
ISSN:0007-0920
1532-1827
DOI:10.1038/bjc.1986.235