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The relief of biliary obstruction in experimental rats by diverting the hepatic lymph into the duodenum

Twelve days after their common bile ducts had been ligated rats were icteric and their hepatic lymph nodes and lymph ducts were two or three times their normal size. Cannulation of the hepatic lymph ducts of these rats yielded bile-stained lymph which flowed at nine times its normal rate. As the lym...

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Published in:International journal of experimental pathology 1991-06, Vol.72 (3), p.345-348
Main Authors: GYURE, L. A, HALL, J. G, LAPIS, K, TIMAR, J
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Language:English
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container_title International journal of experimental pathology
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creator GYURE, L. A
HALL, J. G
LAPIS, K
TIMAR, J
description Twelve days after their common bile ducts had been ligated rats were icteric and their hepatic lymph nodes and lymph ducts were two or three times their normal size. Cannulation of the hepatic lymph ducts of these rats yielded bile-stained lymph which flowed at nine times its normal rate. As the lymph flowed, so the concentration of bilirubin in the blood declined; after 5 days the rats were no longer jaundiced, and by day 11 there were normal amounts of bilirubin in the blood. In another series it proved possible on seven occasions to insert the free end of the hepatic lymph cannula into the duodenum at the time that the bile was obstructed. Five of these animals showed no increase in serum bilirubin and remained in good condition until the experiments were terminated up to 61 days later. It seems that the effects of biliary obstruction can be mitigated by shunting the hepatic lymph into the intestine.
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It seems that the effects of biliary obstruction can be mitigated by shunting the hepatic lymph into the intestine.</description><identifier>ISSN: 0959-9673</identifier><identifier>EISSN: 1365-2613</identifier><identifier>PMID: 1843261</identifier><language>eng</language><publisher>Oxford: Blackwell Science</publisher><subject>Animals ; Biliary Tract Surgical Procedures - methods ; Biological and medical sciences ; Catheterization - methods ; Cholestasis - surgery ; Duodenum - surgery ; Gastroenterology. Liver. Pancreas. Abdomen ; Liver - surgery ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Lymphatic System - surgery ; Male ; Medical sciences ; Other diseases. 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As the lymph flowed, so the concentration of bilirubin in the blood declined; after 5 days the rats were no longer jaundiced, and by day 11 there were normal amounts of bilirubin in the blood. In another series it proved possible on seven occasions to insert the free end of the hepatic lymph cannula into the duodenum at the time that the bile was obstructed. Five of these animals showed no increase in serum bilirubin and remained in good condition until the experiments were terminated up to 61 days later. It seems that the effects of biliary obstruction can be mitigated by shunting the hepatic lymph into the intestine.</abstract><cop>Oxford</cop><pub>Blackwell Science</pub><pmid>1843261</pmid><tpages>4</tpages></addata></record>
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ispartof International journal of experimental pathology, 1991-06, Vol.72 (3), p.345-348
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language eng
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source PubMed Central
subjects Animals
Biliary Tract Surgical Procedures - methods
Biological and medical sciences
Catheterization - methods
Cholestasis - surgery
Duodenum - surgery
Gastroenterology. Liver. Pancreas. Abdomen
Liver - surgery
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Lymphatic System - surgery
Male
Medical sciences
Other diseases. Semiology
Rats
Rats, Wistar
title The relief of biliary obstruction in experimental rats by diverting the hepatic lymph into the duodenum
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