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The relief of biliary obstruction in experimental rats by diverting the hepatic lymph into the duodenum
Twelve days after their common bile ducts had been ligated rats were icteric and their hepatic lymph nodes and lymph ducts were two or three times their normal size. Cannulation of the hepatic lymph ducts of these rats yielded bile-stained lymph which flowed at nine times its normal rate. As the lym...
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Published in: | International journal of experimental pathology 1991-06, Vol.72 (3), p.345-348 |
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creator | GYURE, L. A HALL, J. G LAPIS, K TIMAR, J |
description | Twelve days after their common bile ducts had been ligated rats were icteric and their hepatic lymph nodes and lymph ducts were two or three times their normal size. Cannulation of the hepatic lymph ducts of these rats yielded bile-stained lymph which flowed at nine times its normal rate. As the lymph flowed, so the concentration of bilirubin in the blood declined; after 5 days the rats were no longer jaundiced, and by day 11 there were normal amounts of bilirubin in the blood. In another series it proved possible on seven occasions to insert the free end of the hepatic lymph cannula into the duodenum at the time that the bile was obstructed. Five of these animals showed no increase in serum bilirubin and remained in good condition until the experiments were terminated up to 61 days later. It seems that the effects of biliary obstruction can be mitigated by shunting the hepatic lymph into the intestine. |
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A ; HALL, J. G ; LAPIS, K ; TIMAR, J</creator><creatorcontrib>GYURE, L. A ; HALL, J. G ; LAPIS, K ; TIMAR, J</creatorcontrib><description>Twelve days after their common bile ducts had been ligated rats were icteric and their hepatic lymph nodes and lymph ducts were two or three times their normal size. Cannulation of the hepatic lymph ducts of these rats yielded bile-stained lymph which flowed at nine times its normal rate. As the lymph flowed, so the concentration of bilirubin in the blood declined; after 5 days the rats were no longer jaundiced, and by day 11 there were normal amounts of bilirubin in the blood. In another series it proved possible on seven occasions to insert the free end of the hepatic lymph cannula into the duodenum at the time that the bile was obstructed. Five of these animals showed no increase in serum bilirubin and remained in good condition until the experiments were terminated up to 61 days later. It seems that the effects of biliary obstruction can be mitigated by shunting the hepatic lymph into the intestine.</description><identifier>ISSN: 0959-9673</identifier><identifier>EISSN: 1365-2613</identifier><identifier>PMID: 1843261</identifier><language>eng</language><publisher>Oxford: Blackwell Science</publisher><subject>Animals ; Biliary Tract Surgical Procedures - methods ; Biological and medical sciences ; Catheterization - methods ; Cholestasis - surgery ; Duodenum - surgery ; Gastroenterology. Liver. Pancreas. Abdomen ; Liver - surgery ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Lymphatic System - surgery ; Male ; Medical sciences ; Other diseases. Semiology ; Rats ; Rats, Wistar</subject><ispartof>International journal of experimental pathology, 1991-06, Vol.72 (3), p.345-348</ispartof><rights>1991 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2001945/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC2001945/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,53769,53771</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=19829534$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/1843261$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>GYURE, L. A</creatorcontrib><creatorcontrib>HALL, J. G</creatorcontrib><creatorcontrib>LAPIS, K</creatorcontrib><creatorcontrib>TIMAR, J</creatorcontrib><title>The relief of biliary obstruction in experimental rats by diverting the hepatic lymph into the duodenum</title><title>International journal of experimental pathology</title><addtitle>Int J Exp Pathol</addtitle><description>Twelve days after their common bile ducts had been ligated rats were icteric and their hepatic lymph nodes and lymph ducts were two or three times their normal size. Cannulation of the hepatic lymph ducts of these rats yielded bile-stained lymph which flowed at nine times its normal rate. As the lymph flowed, so the concentration of bilirubin in the blood declined; after 5 days the rats were no longer jaundiced, and by day 11 there were normal amounts of bilirubin in the blood. In another series it proved possible on seven occasions to insert the free end of the hepatic lymph cannula into the duodenum at the time that the bile was obstructed. Five of these animals showed no increase in serum bilirubin and remained in good condition until the experiments were terminated up to 61 days later. It seems that the effects of biliary obstruction can be mitigated by shunting the hepatic lymph into the intestine.</description><subject>Animals</subject><subject>Biliary Tract Surgical Procedures - methods</subject><subject>Biological and medical sciences</subject><subject>Catheterization - methods</subject><subject>Cholestasis - surgery</subject><subject>Duodenum - surgery</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Liver - surgery</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Lymphatic System - surgery</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Other diseases. Semiology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><issn>0959-9673</issn><issn>1365-2613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1991</creationdate><recordtype>article</recordtype><recordid>eNpVUE1LxDAUDKKs6-pPEHLRW6FJ2qa5CLL4BYKX9VyS9nUbSZOapIv77w26-HF68GbevJk5QkvCqjKjFWHHaJmLUmSi4uwUnYXwlueEUcIXaEHqgiXOEm03A2APRkOPXY-VNlr6PXYqRD-3UTuLtcXwMYHXI9goDfYyBqz2uNM78FHbLY5JY4BJRt1isx-nId1E97XuZteBncdzdNJLE-DiMFfo9f5us37Mnl8enta3z9lEBYkZBaEKwkVOlCC9UMA6aDkVJaE1UwJ4V1JeV3mZ91AyWhQ16RSjdZ_nNat6xVbo5lt3mtUIXZsse2maKblPuRondfMfsXpotm7X0FSOKMokcH0Q8O59hhCbUYcWjJEW3BwaTnmZHIhEvPz76efFodqEXx1wGVppei9tq8MvTdQpFivYJ4KqhSE</recordid><startdate>19910601</startdate><enddate>19910601</enddate><creator>GYURE, L. A</creator><creator>HALL, J. G</creator><creator>LAPIS, K</creator><creator>TIMAR, J</creator><general>Blackwell Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19910601</creationdate><title>The relief of biliary obstruction in experimental rats by diverting the hepatic lymph into the duodenum</title><author>GYURE, L. A ; HALL, J. G ; LAPIS, K ; TIMAR, J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p291t-2e9b417901b91f9be3dec72951283b9e7d52786050fe5324481db328f00836fb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1991</creationdate><topic>Animals</topic><topic>Biliary Tract Surgical Procedures - methods</topic><topic>Biological and medical sciences</topic><topic>Catheterization - methods</topic><topic>Cholestasis - surgery</topic><topic>Duodenum - surgery</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Liver - surgery</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Lymphatic System - surgery</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Other diseases. Semiology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>GYURE, L. A</creatorcontrib><creatorcontrib>HALL, J. G</creatorcontrib><creatorcontrib>LAPIS, K</creatorcontrib><creatorcontrib>TIMAR, J</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of experimental pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>GYURE, L. A</au><au>HALL, J. G</au><au>LAPIS, K</au><au>TIMAR, J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The relief of biliary obstruction in experimental rats by diverting the hepatic lymph into the duodenum</atitle><jtitle>International journal of experimental pathology</jtitle><addtitle>Int J Exp Pathol</addtitle><date>1991-06-01</date><risdate>1991</risdate><volume>72</volume><issue>3</issue><spage>345</spage><epage>348</epage><pages>345-348</pages><issn>0959-9673</issn><eissn>1365-2613</eissn><abstract>Twelve days after their common bile ducts had been ligated rats were icteric and their hepatic lymph nodes and lymph ducts were two or three times their normal size. Cannulation of the hepatic lymph ducts of these rats yielded bile-stained lymph which flowed at nine times its normal rate. As the lymph flowed, so the concentration of bilirubin in the blood declined; after 5 days the rats were no longer jaundiced, and by day 11 there were normal amounts of bilirubin in the blood. In another series it proved possible on seven occasions to insert the free end of the hepatic lymph cannula into the duodenum at the time that the bile was obstructed. Five of these animals showed no increase in serum bilirubin and remained in good condition until the experiments were terminated up to 61 days later. It seems that the effects of biliary obstruction can be mitigated by shunting the hepatic lymph into the intestine.</abstract><cop>Oxford</cop><pub>Blackwell Science</pub><pmid>1843261</pmid><tpages>4</tpages></addata></record> |
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subjects | Animals Biliary Tract Surgical Procedures - methods Biological and medical sciences Catheterization - methods Cholestasis - surgery Duodenum - surgery Gastroenterology. Liver. Pancreas. Abdomen Liver - surgery Liver. Biliary tract. Portal circulation. Exocrine pancreas Lymphatic System - surgery Male Medical sciences Other diseases. Semiology Rats Rats, Wistar |
title | The relief of biliary obstruction in experimental rats by diverting the hepatic lymph into the duodenum |
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