Radiation-induced Osteosarcoma in the Rat as a Model for Osteosarcoma in Man

A technique is described for the local induction of osteosarcoma in the rat by implanting 32 P-impregnated polyvinyl chloride discs into the distal femoral metaphysis. The incidence of osteosarcomata after 18 months was 28%. A comparison is made of the pathology of the radiation-induced osteosarcoma...

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Bibliographic Details
Published in:British journal of cancer 1970-06, Vol.24 (2), p.294-299
Main Author: Cobb, L M
Format: Article
Language:English
Subjects:
Animals
Biomedicine
Cancer Research
Disease Models, Animal
Drug Resistance
Epidemiology
Female
Molecular Medicine
Neoplasm Transplantation
Neoplasms, Radiation-Induced
Oncology
original-article
Osteosarcoma - diagnostic imaging
Osteosarcoma - etiology
Osteosarcoma - pathology
Phosphorus Isotopes
Polyvinyls
Radiography
Rats
Sarcoma, Experimental
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Summary:A technique is described for the local induction of osteosarcoma in the rat by implanting 32 P-impregnated polyvinyl chloride discs into the distal femoral metaphysis. The incidence of osteosarcomata after 18 months was 28%. A comparison is made of the pathology of the radiation-induced osteosarcoma in the rat and the “spontaneous” osteosarcoma in man. The possible value of the rat osteosarcoma model is discussed.
ISSN:0007-0920
1532-1827
DOI:10.1038/bjc.1970.34