The Carcinogenicity of Two Diazadibenzopyrenes

1,12-Diazadibenzo(a,i)pyrene (I), an isostere of the extremely potent carcinogen dibenzo(a,i)pyrene, also displays carcinogenicity although to a considerably lesser degree than the latter compound. While dibenzo(a,h)pyrene is known to be distinctly less active than dibenzo(a,i)pyrene, surprisingly 4...

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Bibliographic Details
Published in:British journal of cancer 1972-08, Vol.26 (4), p.262-264
Main Authors: Zajdela, F, Buu-Hoï, N P, Jacquignon, P, Dufour, M
Format: Article
Language:English
Subjects:
Animals
Aza Compounds - pharmacology
Benzopyrenes - pharmacology
Biomedical and Life Sciences
Biomedicine
Cancer Research
Carcinogens
Drug Resistance
Epidemiology
Injections, Subcutaneous
Mice
Molecular Medicine
Oncology
original-article
Sarcoma, Experimental - chemically induced
Structure-Activity Relationship
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Summary:1,12-Diazadibenzo(a,i)pyrene (I), an isostere of the extremely potent carcinogen dibenzo(a,i)pyrene, also displays carcinogenicity although to a considerably lesser degree than the latter compound. While dibenzo(a,h)pyrene is known to be distinctly less active than dibenzo(a,i)pyrene, surprisingly 4,11-diazadibenzo(a,h)pyrene (II) shows a greater activity than I. Another hexacyclic diaza-hydrocarbon, 4,12-diazadibenzo(g,p)chrysene (III), which is devoid of a meso-phenanthrenic region, proved totally inactive.
ISSN:0007-0920
1532-1827
DOI:10.1038/bjc.1972.35