Levels of adenosine deaminase in some experimental animal tumours and the possible therapeutic effect of the ADA inhibitor 2-deoxy-coformycin

The intracellular adenosine deaminase activities (ADA) in 12 different experimental animal tumours were measured. Unlike the leukaemic lymphoblasts of man, those of two spontaneous rat leukaemias did not have elevated levels of the enzyme. Very high levels were found in a rat plasma-cell tumour (IR...

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Bibliographic Details
Published in:British journal of cancer 1979-11, Vol.40 (5), p.750-754
Main Authors: Hall, J G, Gyure, L, Peppard, J, Orlans, E
Format: Article
Language:English
Subjects:
Adenosine Deaminase - metabolism
Adenosine Deaminase Inhibitors
Animals
Biomedical and Life Sciences
Biomedicine
Cancer Research
Coformycin - analogs & derivatives
Coformycin - pharmacology
Drug Resistance
Epidemiology
Mice
Molecular Medicine
Neoplasms, Experimental - drug therapy
Neoplasms, Experimental - enzymology
Nucleoside Deaminases - metabolism
Oncology
original-article
Plasmacytoma - drug therapy
Rats
Ribonucleosides - analogs & derivatives
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Summary:The intracellular adenosine deaminase activities (ADA) in 12 different experimental animal tumours were measured. Unlike the leukaemic lymphoblasts of man, those of two spontaneous rat leukaemias did not have elevated levels of the enzyme. Very high levels were found in a rat plasma-cell tumour (IR 461) and an attempt was made to treat such tumours with the specific enzyme inhibitor, 2-deoxy-coformycin. The shortage of this drug prevented a systematic study, but a daily dose of 8 mg/kg had a significant inhibitory effect on the growth of tumours.
ISSN:0007-0920
1532-1827
DOI:10.1038/bjc.1979.256